@jpirruccello @hmkyale @JACCJournals @ACCinTouch @medrxivpreprint @jsross119 I thought they already accepted preprints... https://t.co/z6zJQnoTUE @biorxiv_genetic https://t.co/rhbyxMjtql @JACCJournals cc @minouye271 @GadAbraham1

🤟 replication of predictive accuracy of PRS for CAD in Canadians (AUC=0.72-0.89). 🤔 reported values of AUC correspond to a score that includes other variables. AUC for PRS only is much smaller for CAD (AUC=0.60-0.65), see e.g. https://t.co/8QzP2JTg9z http

Good stuff on my thesis lol

@GenomeNathan i.e. the only thing that would be terrifying about that would be the chance of being left handed if one were already presidency Might be worth having a look at these papers to see what people mean by genomic risk https://t.co/hyLaS49jLM http

RT @minouye271: @OzCvA Let's start with stimulating research into genomic risk scores for heart disease. Our 49k GRS (https://t.co/hyLaS49j…

RT @minouye271: @OzCvA Let's start with stimulating research into genomic risk scores for heart disease. Our 49k GRS (https://t.co/hyLaS49j…

@OzCvA Let's start with stimulating research into genomic risk scores for heart disease. Our 49k GRS (https://t.co/hyLaS49jLM) has been shown to change behavior: stop smoking, lose weight, see doc more. https://t.co/IGtutiXDP7 Our new metaGRS likely more

RT @ATorkamani: You mean these sequels? https://t.co/b911biaR8u https://t.co/6ptHp0UVdl Sometimes the sequel is better than the original.…

You mean these sequels? https://t.co/b911biaR8u https://t.co/6ptHp0UVdl Sometimes the sequel is better than the original. https://t.co/IsRbEJek28

RT @EricTopol: Coronary heart disease: now a meta genomic risk score transcends and supplements established clinical risk factors (N=500,00…

Genomic risk prediction of coronary artery disease in nearly 500,000 adults: implications for early screening and primary prevention https://t.co/v4F8VSoJww #pmwc18

RT @minouye271: Here's some reading for scientists doing research on PRSs/GRSs Software https://t.co/Nj27oH3iOW Methods https://t.co/DerjB…

RT @minouye271: Here's some reading for scientists doing research on PRSs/GRSs Software https://t.co/Nj27oH3iOW Methods https://t.co/DerjB…

RT @minouye271: Here's some reading for scientists doing research on PRSs/GRSs Software https://t.co/Nj27oH3iOW Methods https://t.co/DerjB…

@ATorkamani @NathanWineinger @EricTopol @GadAbraham1 Also to note, we don't focus on developing methods. We're very applied. https://t.co/9y1oNVFggt

RT @minouye271: Here's some reading for scientists doing research on PRSs/GRSs Software https://t.co/Nj27oH3iOW Methods https://t.co/DerjB…

RT @minouye271: Here's some reading for scientists doing research on PRSs/GRSs Software https://t.co/Nj27oH3iOW Methods https://t.co/DerjB…

RT @minouye271: Here's some reading for scientists doing research on PRSs/GRSs Software https://t.co/Nj27oH3iOW Methods https://t.co/DerjB…

RT @minouye271: Here's some reading for scientists doing research on PRSs/GRSs Software https://t.co/Nj27oH3iOW Methods https://t.co/DerjB…

RT @minouye271: Here's some reading for scientists doing research on PRSs/GRSs Software https://t.co/Nj27oH3iOW Methods https://t.co/DerjB…

Here's some reading for scientists doing research on PRSs/GRSs Software https://t.co/Nj27oH3iOW Methods https://t.co/DerjBEClDk Celiac https://t.co/c6mPS5IkfH Review https://t.co/Yj5wcAcsPf Celiac2 https://t.co/0vMM5dpwaU CAD https://t.co/hyLaS3RIUe CAD2

RT @MarkusPerola: @BP_Teemu Polygeeninen riskisumma isompi riski CHDlle UK Biopankissa paremmin kuin tupakointi/BMI/hypertensio/DM. https:/…

@BP_Teemu Polygeeninen riskisumma isompi riski CHDlle UK Biopankissa paremmin kuin tupakointi/BMI/hypertensio/DM. https://t.co/eLmHH6d9Z0 Muitakin esimerkkejä on. Kyllä PRS on useille kansantaudeille merkittävä ja hyvin todenäköisesti toisi lisäarvoa riski

RT @skathire: Instead of vaguely describing work as ‘embarassing’, would love to have you read the 2 papers and detail your specific statis…

RT @minouye271: @ErickRScott @cecilejanssens @euanashley @samrip @ewanbirney @DrMJoyner @skathire @mendel_random Would love to see you open…

@ErickRScott @cecilejanssens @euanashley @samrip @ewanbirney @DrMJoyner @skathire @mendel_random Would love to see you openly review our preprint and perform your own analysis with the metaGRS. The link to it is in the preprint https://t.co/7Q2M269kwU

RT @Piwdb: Great thread for those interested in whether #genomics can be used for risk prediction (and subsequent treatment) https://t.co/c…

RT @Piwdb: Great thread for those interested in whether #genomics can be used for risk prediction (and subsequent treatment) https://t.co/c…

RT @Piwdb: Great thread for those interested in whether #genomics can be used for risk prediction (and subsequent treatment) https://t.co/c…

Great thread for those interested in whether #genomics can be used for risk prediction (and subsequent treatment) https://t.co/c9oDEdfuOS

RT @ProfDFrancis: Watching Sek and Cecille Janssens debate this on Twitter tells my why this is the future of scientific debate. Titans of…

RT @ProfDFrancis: Watching Sek and Cecille Janssens debate this on Twitter tells my why this is the future of scientific debate. Titans of…

RT @laurahercher: Thread: these 2 are doing a webinar together and everyone should watch. This is like the weighing in before a boxing matc…

RT @minouye271: Read this thread. It has a happy ending. https://t.co/syV2QR2yLM

RT @ProfDFrancis: Watching Sek and Cecille Janssens debate this on Twitter tells my why this is the future of scientific debate. Titans of…

RT @ProfDFrancis: Watching Sek and Cecille Janssens debate this on Twitter tells my why this is the future of scientific debate. Titans of…

RT @minouye271: Fantastic perspective on the current challenges and future promise of genomic risk scores for cardiovascular diseases. Key…

RT @ProfDFrancis: Watching Sek and Cecille Janssens debate this on Twitter tells my why this is the future of scientific debate. Titans of…

RT @ProfDFrancis: Watching Sek and Cecille Janssens debate this on Twitter tells my why this is the future of scientific debate. Titans of…

RT @ProfDFrancis: Watching Sek and Cecille Janssens debate this on Twitter tells my why this is the future of scientific debate. Titans of…

RT @ProfDFrancis: Watching Sek and Cecille Janssens debate this on Twitter tells my why this is the future of scientific debate. Titans of…

RT @ProfDFrancis: Watching Sek and Cecille Janssens debate this on Twitter tells my why this is the future of scientific debate. Titans of…

RT @ProfDFrancis: Watching Sek and Cecille Janssens debate this on Twitter tells my why this is the future of scientific debate. Titans of…

Watching Sek and Cecille Janssens debate this on Twitter tells my why this is the future of scientific debate. Titans of their field, they are happy to mock each other's point of view, while remaining friendly. _That_ is science. Give me that any day ove

RT @laurahercher: Thread: these 2 are doing a webinar together and everyone should watch. This is like the weighing in before a boxing matc…

RT @minouye271: Read this thread. It has a happy ending. https://t.co/syV2QR2yLM

RT @minouye271: Read this thread. It has a happy ending. https://t.co/syV2QR2yLM

RT @minouye271: Read this thread. It has a happy ending. https://t.co/syV2QR2yLM

RT @skathire: Instead of vaguely describing work as ‘embarassing’, would love to have you read the 2 papers and detail your specific statis…

Thread: these 2 are doing a webinar together and everyone should watch. This is like the weighing in before a boxing match, only it's the other sort of weighing in. #gcchat #takintheshowontheroad https://t.co/UkOXAagZTS

RT @minouye271: Fantastic perspective on the current challenges and future promise of genomic risk scores for cardiovascular diseases. Key…

RT @minouye271: Fantastic perspective on the current challenges and future promise of genomic risk scores for cardiovascular diseases. Key…

RT @skathire: Instead of vaguely describing work as ‘embarassing’, would love to have you read the 2 papers and detail your specific statis…

So much scientific debate in this thread https://t.co/cDLwLUfIRv

Read this thread. It has a happy ending. https://t.co/syV2QR2yLM

Important thread. https://t.co/QZgaGfePgn

RT @skathire: Instead of vaguely describing work as ‘embarassing’, would love to have you read the 2 papers and detail your specific statis…

RT @skathire: Instead of vaguely describing work as ‘embarassing’, would love to have you read the 2 papers and detail your specific statis…

Instead of vaguely describing work as ‘embarassing’, would love to have you read the 2 papers and detail your specific statistical critiques. https://t.co/Qlcw60K0lH https://t.co/6EQ2E0A68n The statisticians who have reviewed our work actually ❤️ it!

RT @minouye271: Fantastic perspective on the current challenges and future promise of genomic risk scores for cardiovascular diseases. Key…

RT @minouye271: Fantastic perspective on the current challenges and future promise of genomic risk scores for cardiovascular diseases. Key…

@minouye271 @euanashley @joshuawknowles @biorxivpreprint @cshperspectives Here are the 2 @biorxivpreprint: https://t.co/Qlcw60K0lH https://t.co/6EQ2E0A68n @cshperspectives

@minouye271 @ewanbirney @genetisaur @minouye271 and @GadAbraham1 important contributions to this space 👇 https://t.co/f7KKbbTAXY https://t.co/6EQ2E0A68n

RT @minouye271: Fantastic perspective on the current challenges and future promise of genomic risk scores for cardiovascular diseases. Key…

RT @minouye271: Fantastic perspective on the current challenges and future promise of genomic risk scores for cardiovascular diseases. Key…

RT @minouye271: Fantastic perspective on the current challenges and future promise of genomic risk scores for cardiovascular diseases. Key…

Fantastic perspective on the current challenges and future promise of genomic risk scores for cardiovascular diseases. Key background reading for @uk_biobank: https://t.co/7Q2M269kwU https://t.co/TD9c2nceJ2 And previously w/metabochip: https://t.co/hyLaS

Study validated in two add’l datasets. Marker more sig in women. AUC looks interesting relative to GRS (0.68) & CAC (0.76). https://t.co/ALIlKXy833 https://t.co/rlw4Mi99Pi

RT @EricTopol: Coronary heart disease: now a meta genomic risk score transcends and supplements established clinical risk factors (N=500,00…

RT @minouye271: Can’t help but point out the study covered here is only using a fraction of SNPs identified in 2015. The field has moved wa…

Can’t help but point out the study covered here is only using a fraction of SNPs identified in 2015. The field has moved way beyond this with far more powerful GRSs... https://t.co/50ewsexyYZ https://t.co/ZtUhnADRPZ

RT @minouye271: Thrilled to be part of this from UK Biobank CardioMetabolic Working Group Genomic risk prediction of coronary artery disea…

RT @euanashley: Polygenic risk scores have arrived https://t.co/TGZkCprxFP https://t.co/czJpD3Noou

Stronger predictor than any single traditional risk factor https://t.co/JRGOLub4J2

RT @euanashley: Polygenic risk scores have arrived https://t.co/TGZkCprxFP https://t.co/czJpD3Noou

RT @euanashley: Polygenic risk scores have arrived https://t.co/TGZkCprxFP https://t.co/czJpD3Noou

RT @JosephPowell_UQ: Genomic risk prediction of coronary artery disease in nearly 500,000 adults: implications for early screening and prim…

RT @GadAbraham1: ... and only getting better with time! https://t.co/ejJXk1pBXG

RT @euanashley: Polygenic risk scores have arrived https://t.co/TGZkCprxFP https://t.co/czJpD3Noou

RT @euanashley: Polygenic risk scores have arrived https://t.co/TGZkCprxFP https://t.co/czJpD3Noou

RT @JosephPowell_UQ: Genomic risk prediction of coronary artery disease in nearly 500,000 adults: implications for early screening and prim…

RT @euanashley: Polygenic risk scores have arrived https://t.co/TGZkCprxFP https://t.co/czJpD3Noou

RT @euanashley: Polygenic risk scores have arrived https://t.co/TGZkCprxFP https://t.co/czJpD3Noou

RT @euanashley: Polygenic risk scores have arrived https://t.co/TGZkCprxFP https://t.co/czJpD3Noou

RT @euanashley: Polygenic risk scores have arrived https://t.co/TGZkCprxFP https://t.co/czJpD3Noou

RT @euanashley: Polygenic risk scores have arrived https://t.co/TGZkCprxFP https://t.co/czJpD3Noou

RT @euanashley: Polygenic risk scores have arrived https://t.co/TGZkCprxFP https://t.co/czJpD3Noou

Genomic risk prediction of coronary artery disease in nearly 500,000 adults: implications for early screening and primary prevention https://t.co/WyqOJ6LGKi

They have indeed :) @manuelrivascruz https://t.co/ZxGvdy9eAg

... and only getting better with time! https://t.co/ejJXk1pBXG

Polygenic risk scores have arrived https://t.co/TGZkCprxFP https://t.co/czJpD3Noou

RT @EricTopol: Coronary heart disease: now a meta genomic risk score transcends and supplements established clinical risk factors (N=500,00…

RT @razibkhan: Genomic risk prediction of coronary artery disease in nearly 500,000 adults: implications for early screening and primary pr…

RT @DrKatHolt: Brilliant work from @minouye271 @GadAbraham1 and their many great colleagues! https://t.co/HyACP77FcZ

RT @EricTopol: Coronary heart disease: now a meta genomic risk score transcends and supplements established clinical risk factors (N=500,00…

RT @EricTopol: Coronary heart disease: now a meta genomic risk score transcends and supplements established clinical risk factors (N=500,00…

Very interesting work. Particularly in association with treatment regimes. https://t.co/937jc7UyDT

Brilliant work from @minouye271 @GadAbraham1 and their many great colleagues! https://t.co/HyACP77FcZ

RT @minouye271: Important finding from UKB CardioMetabolic Group: Even in people on the proven treatments for CAD risk (lipid &/or BP lower…

RT @rplenge: “The metaGRS had higher C-index (C=0.623, 95% CI 0.615-0.631) for incident CAD than any of four conventional factors (smoking,…