Guy Sella then shows a modified image from https://t.co/sBy5urMOma @jkpritch's lab He then consideres heritable variable: h^2 proportional to 2a^2 x(1-x) x: minor allele frequency a^2: alpha^2 gamma^2 alpha^2: SNP cis effect gamma^2: gene importance #
RT @nmaehler: The pain of running into that paywall though... Here's the preprint: https://t.co/KdFjR2xGZY https://t.co/3CfZ6d0tL8
The pain of running into that paywall though... Here's the preprint: https://t.co/KdFjR2xGZY https://t.co/3CfZ6d0tL8
RT @XuanyaoLiu: Our work on understanding the importance of trans-regulatory effects in complex traits is out! We believe that future studi…
Li: Trans effects tend to be much smaller than cis effects, so 70% trans effects implies many thousands of genes w/small effects responsible for most of the genetic variance. Expression covariance positive -> contribution of trans effects stronger https
RT @jkpritch: @UCDflowerpower @PlantEvolution In our definition, core genes are those genes that have direct effects on phenotype not media…
RT @jkpritch: @UCDflowerpower @PlantEvolution In our definition, core genes are those genes that have direct effects on phenotype not media…
@UCDflowerpower @PlantEvolution In our definition, core genes are those genes that have direct effects on phenotype not mediated through regulatory networks. We also reserve a special role for master regulator genes although these are not core by this defi
RT @TroyNRowan: If you want to read more about the model, check these papers out: https://t.co/8RIkS6eAwK https://t.co/50XyEUKsmp #PAGXX…
RT @TroyNRowan: If you want to read more about the model, check these papers out: https://t.co/8RIkS6eAwK https://t.co/50XyEUKsmp #PAGXX…
RT @TroyNRowan: If you want to read more about the model, check these papers out: https://t.co/8RIkS6eAwK https://t.co/50XyEUKsmp #PAGXX…
If you want to read more about the model, check these papers out: https://t.co/8RIkS6eAwK https://t.co/50XyEUKsmp #PAGXXVII
#PAGXXVII More on role of trans effects in inheritance described by Jonathan Pritchard: https://t.co/BQnzXF09Su
RT @Graham_Coop: @EvolOdonata Not a fan of the name. However, I think that the model that makes predictions about how trans changes in gene…
RT @jkpritch: @EvolOdonata PS, if you're actually interested and not just trolling, you might like to read the sequel which expands the mat…
@EvolOdonata PS, if you're actually interested and not just trolling, you might like to read the sequel which expands the mathematical modeling: https://t.co/zfxhluVllW
@EvolOdonata The point of the omni model, to me, seems to be to build towards a quantitative model of genomics. https://t.co/MOfNqtJDyx
RT @Graham_Coop: @EvolOdonata Not a fan of the name. However, I think that the model that makes predictions about how trans changes in gene…
@EvolOdonata Not a fan of the name. However, I think that the model that makes predictions about how trans changes in gene expression lead to a incredibly polygenic architecture is useful & quite different from Lande's work. See https://t.co/UqcEUVcNe
RT @yang_i_li: I am super thrilled to share new work on the Omnigenic model with @jkpritch and @XuanyaoLiu! We've been working on this for…
Examples of papers that live in that question mark box: the omnigenetic linear model of genomics https://t.co/QBMKOsrrda
RT @AnnejaneF: Many papers were referenced during the talks, but mostly centered around these recent pieces: https://t.co/eDOpR0pmYe and h…
Many papers were referenced during the talks, but mostly centered around these recent pieces: https://t.co/eDOpR0pmYe and https://t.co/A1wsvldNNp
Trans effects on gene expression can drive omnigenic inheritance https://t.co/Ho3feQEmP6
RT @StatGenDan: .@jkpritch Most of h^2 likely driven by sum of huge numbers of small effects w random directions; may be weakly related to…
.@jkpritch Most of h^2 likely driven by sum of huge numbers of small effects w random directions; may be weakly related to biology of the trait. Expect core genes & peripheral master regulators to dominate top hits. https://t.co/HugaUKW7Wo #ASHG18
Always love hearing @jkpritch talk about anything, but excited to hear him talking about the new work on the omnigenic model: https://t.co/HfxZABQ9HF #ASHG18 @XuanyaoLiu @yang_i_li
.@jkpritch talks about work from pre-print from @XuanyaoLiu : https://t.co/LMScOgcaMg
Interesting work from @jkpritch's lab on the genetic architecture of complex traits https://t.co/o9b5yjvsNq
RT @jkpritch: Thanks so much for the invitation to speak tomorrow at #wcpg2018! I'll talk mainly about our latest paper on complex trait ar…
RT @jkpritch: Thanks so much for the invitation to speak tomorrow at #wcpg2018! I'll talk mainly about our latest paper on complex trait ar…
RT @carlzimmer: The Omnigenic Model enters its next stage of life. For the story up till now, see 1. @vero_greenwood https://t.co/nOIozcghe…
RT @jkpritch: Thanks so much for the invitation to speak tomorrow at #wcpg2018! I'll talk mainly about our latest paper on complex trait ar…
RT @jkpritch: Thanks so much for the invitation to speak tomorrow at #wcpg2018! I'll talk mainly about our latest paper on complex trait ar…
RT @mbeisen: @lpachter @leonidkruglyak @TriggerLoop @skathire And there's a followup here: https://t.co/VRXlZvi6cd
@lpachter @leonidkruglyak @TriggerLoop @skathire And there's a followup here: https://t.co/VRXlZvi6cd
RT @carlzimmer: The Omnigenic Model enters its next stage of life. For the story up till now, see 1. @vero_greenwood https://t.co/nOIozcghe…
RT @jkpritch: Thanks so much for the invitation to speak tomorrow at #wcpg2018! I'll talk mainly about our latest paper on complex trait ar…
RT @jkpritch: Thanks so much for the invitation to speak tomorrow at #wcpg2018! I'll talk mainly about our latest paper on complex trait ar…
@amyiorkas
RT @jkpritch: Thanks so much for the invitation to speak tomorrow at #wcpg2018! I'll talk mainly about our latest paper on complex trait ar…
RT @timfrayling: @jkpritch @jkpritch latest "omnigenic paper : https://t.co/BQL3BU8cnI The obesity-associated SNP in FTO not a good example…
RT @Joni_Coleman: Key omnigenic papers: https://t.co/2Dn6hgas0G 2/2 #WCPG2018
Key omnigenic papers: https://t.co/2Dn6hgas0G 2/2 #WCPG2018
RT @timfrayling: @jkpritch @jkpritch latest "omnigenic paper : https://t.co/BQL3BU8cnI The obesity-associated SNP in FTO not a good example…
@jkpritch @jkpritch latest "omnigenic paper : https://t.co/BQL3BU8cnI The obesity-associated SNP in FTO not a good example. Evidence is this variant alters many traits via SNP > BMI > many BMI related traits, not SNP > many genes >> many tra
RT @jkpritch: Thanks so much for the invitation to speak tomorrow at #wcpg2018! I'll talk mainly about our latest paper on complex trait ar…
RT @jkpritch: Thanks so much for the invitation to speak tomorrow at #wcpg2018! I'll talk mainly about our latest paper on complex trait ar…
RT @jkpritch: Thanks so much for the invitation to speak tomorrow at #wcpg2018! I'll talk mainly about our latest paper on complex trait ar…
RT @jkpritch: Thanks so much for the invitation to speak tomorrow at #wcpg2018! I'll talk mainly about our latest paper on complex trait ar…
RT @jkpritch: Thanks so much for the invitation to speak tomorrow at #wcpg2018! I'll talk mainly about our latest paper on complex trait ar…
RT @jkpritch: Thanks so much for the invitation to speak tomorrow at #wcpg2018! I'll talk mainly about our latest paper on complex trait ar…
RT @jkpritch: Thanks so much for the invitation to speak tomorrow at #wcpg2018! I'll talk mainly about our latest paper on complex trait ar…
RT @jkpritch: Thanks so much for the invitation to speak tomorrow at #wcpg2018! I'll talk mainly about our latest paper on complex trait ar…
RT @jkpritch: Thanks so much for the invitation to speak tomorrow at #wcpg2018! I'll talk mainly about our latest paper on complex trait ar…
RT @jkpritch: Thanks so much for the invitation to speak tomorrow at #wcpg2018! I'll talk mainly about our latest paper on complex trait ar…
RT @jkpritch: Thanks so much for the invitation to speak tomorrow at #wcpg2018! I'll talk mainly about our latest paper on complex trait ar…
RT @jkpritch: Thanks so much for the invitation to speak tomorrow at #wcpg2018! I'll talk mainly about our latest paper on complex trait ar…
RT @jkpritch: Thanks so much for the invitation to speak tomorrow at #wcpg2018! I'll talk mainly about our latest paper on complex trait ar…
Thanks so much for the invitation to speak tomorrow at #wcpg2018! I'll talk mainly about our latest paper on complex trait architecture (aka Omnigenic2): https://t.co/f2l1VI1WB4
RT @yang_i_li: I am super thrilled to share new work on the Omnigenic model with @jkpritch and @XuanyaoLiu! We've been working on this for…
RT @yang_i_li: I am super thrilled to share new work on the Omnigenic model with @jkpritch and @XuanyaoLiu! We've been working on this for…
RT @yang_i_li: I am super thrilled to share new work on the Omnigenic model with @jkpritch and @XuanyaoLiu! We've been working on this for…
RT @yang_i_li: I am super thrilled to share new work on the Omnigenic model with @jkpritch and @XuanyaoLiu! We've been working on this for…
RT @yang_i_li: I am super thrilled to share new work on the Omnigenic model with @jkpritch and @XuanyaoLiu! We've been working on this for…
RT @yang_i_li: I am super thrilled to share new work on the Omnigenic model with @jkpritch and @XuanyaoLiu! We've been working on this for…
@PdraicFlood @SpicyBotrytis @joe_pickrell Omnigenic defines a mechanism. Polygenicity doesn't. Omnigenicity is a special case of polygenicity. See the def. in https://t.co/4ozZ64unwk
RT @yang_i_li: I am super thrilled to share new work on the Omnigenic model with @jkpritch and @XuanyaoLiu! We've been working on this for…
RT @yang_i_li: I am super thrilled to share new work on the Omnigenic model with @jkpritch and @XuanyaoLiu! We've been working on this for…
@JackBrackney Not sure what happened, but I eventually found (from Sept. 24) the tweet with the thread I meant to link: https://t.co/CLQqji4S01
RT @biorxivpreprint: Trans effects on gene expression can drive omnigenic inheritance https://t.co/IlQsKU5XbX #bioRxiv
RT @Joni_Coleman: This thread is an excellent discussion of the difficulties of going from genetic variants -> behaviour and of thinking ab…
RT @yang_i_li: I am super thrilled to share new work on the Omnigenic model with @jkpritch and @XuanyaoLiu! We've been working on this for…
This thread is an excellent discussion of the difficulties of going from genetic variants -> behaviour and of thinking about genetic architecture (and now I'm even more excited for @jkpritch and @WrayNaomi plenary at #WCPG2018 !)
RT @yang_i_li: I am super thrilled to share new work on the Omnigenic model with @jkpritch and @XuanyaoLiu! We've been working on this for…
RT @yang_i_li: I am super thrilled to share new work on the Omnigenic model with @jkpritch and @XuanyaoLiu! We've been working on this for…
RT @biorxiv_genetic: Trans effects on gene expression can drive omnigenic inheritance https://t.co/4d8sLF0kx5 #biorxiv_genetic
RT @yang_i_li: I am super thrilled to share new work on the Omnigenic model with @jkpritch and @XuanyaoLiu! We've been working on this for…
RT @XuanyaoLiu: Our work on understanding the importance of trans-regulatory effects in complex traits is out! We believe that future studi…
RT @yang_i_li: I am super thrilled to share new work on the Omnigenic model with @jkpritch and @XuanyaoLiu! We've been working on this for…
RT @silParacchini: Interesting thread and discussion with @WiringTheBrain https://t.co/ZuxvCPOaLm
RT @yang_i_li: I am super thrilled to share new work on the Omnigenic model with @jkpritch and @XuanyaoLiu! We've been working on this for…
RT @silParacchini: Interesting thread and discussion with @WiringTheBrain https://t.co/ZuxvCPOaLm
RT @yang_i_li: I am super thrilled to share new work on the Omnigenic model with @jkpritch and @XuanyaoLiu! We've been working on this for…
RT @XuanyaoLiu: Our work on understanding the importance of trans-regulatory effects in complex traits is out! We believe that future studi…
Interesting thread and discussion with @WiringTheBrain
RT @yang_i_li: I am super thrilled to share new work on the Omnigenic model with @jkpritch and @XuanyaoLiu! We've been working on this for…
RT @yang_i_li: I am super thrilled to share new work on the Omnigenic model with @jkpritch and @XuanyaoLiu! We've been working on this for…
RT @yang_i_li: I am super thrilled to share new work on the Omnigenic model with @jkpritch and @XuanyaoLiu! We've been working on this for…
RT @yang_i_li: I am super thrilled to share new work on the Omnigenic model with @jkpritch and @XuanyaoLiu! We've been working on this for…
RT @philipcball: Interesting, for sure... https://t.co/dTjBYRa723
Interesting, for sure...
RT @yang_i_li: I am super thrilled to share new work on the Omnigenic model with @jkpritch and @XuanyaoLiu! We've been working on this for…
RT @yang_i_li: I am super thrilled to share new work on the Omnigenic model with @jkpritch and @XuanyaoLiu! We've been working on this for…
RT @yang_i_li: I am super thrilled to share new work on the Omnigenic model with @jkpritch and @XuanyaoLiu! We've been working on this for…
RT @yang_i_li: I am super thrilled to share new work on the Omnigenic model with @jkpritch and @XuanyaoLiu! We've been working on this for…
RT @yang_i_li: I am super thrilled to share new work on the Omnigenic model with @jkpritch and @XuanyaoLiu! We've been working on this for…
RT @yang_i_li: I am super thrilled to share new work on the Omnigenic model with @jkpritch and @XuanyaoLiu! We've been working on this for…
The son of Omnigenic ! Move over polygenic.😃
RT @yang_i_li: I am super thrilled to share new work on the Omnigenic model with @jkpritch and @XuanyaoLiu! We've been working on this for…