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RT @anshulkundaje: A must read for folks developing computational methods for enh-promoter interactions. Note how supervised ML methods tra…
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17,521 followers
@jengreitz @Eric_Fauman @anshulkundaje For those following along, ABC paper is: https://t.co/tqOKvzOk2s
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@khanaziz84 @ZhipingWeng @GenomeBiology The data in recent https://t.co/HoDIbgV36F can be used for benchmarking
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RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
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RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
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RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
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RT @jengreitz: We are integrating these approaches with human genetic data, stem cell engineering, and animal models to understand how gene…
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Enjoyed hearing from the horse's mouth (to use an unflattering idiom) the predictive power of a surprisingly simple model of activation by enhancers. Thanks @jengreitz for visiting the @TjianDarzacq lab and restoring my faith that gene regulation is not in
1,482 followers
RT @jengreitz: We are integrating these approaches with human genetic data, stem cell engineering, and animal models to understand how gene…
3,691 followers
We are integrating these approaches with human genetic data, stem cell engineering, and animal models to understand how genetic risk variants for heart diseases affect vascular development and function. https://t.co/UCHpiOZTsE 4/
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@anshulkundaje @jengreitz very nice paper https://t.co/aKKFV3Bvr5 but I can not find where I can download the tool
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RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
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RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
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RT @jengreitz: Our latest is on bioRxiv: https://t.co/YFyVGJGTQ0 Q: Can we predict which enhancers regulate which genes in the human genom…
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@Eric_Fauman @manuelrivascruz @NatureGenet @michaelwainberg @bpasaniuc @hakyim There is promising work in the the community of folks working on enhancer-gene linking approaches that builds on proximity and can outperform it in predicting effects of enhance
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Which enhancers regulate which genes, in which cells? Jesse Engreitz @jengreitz presents work on experimentally mapping thousands of enhancer-gene connections, and a model to predict new connections. On bioRxiv now from @FulcoCharles and co. https://t.co/j
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Preprint by @FulcoCharles, @jengreitz, @eric_lander and many others here: https://t.co/B2zZA1klr5
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RT @jengreitz: Our latest is on bioRxiv: https://t.co/YFyVGJGTQ0 Q: Can we predict which enhancers regulate which genes in the human genom…
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RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
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RT @generegulation: Activity-by-Contact model of enhancer specificity from thousands of CRISPR perturbations https://t.co/bChISR02AE Enhanc…
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RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
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Want to know "which enhancers regulate which genes in which cell types?", read this exciting new paper from @jengreitz @FulcoCharles @eric_lander https://t.co/yDQr5s07uN and/or come to Harvard Northwest Building 353 at 5pm today! https://t.co/lZ2dQma4ij @
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RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
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Activity-by-Contact model of enhancer specificity from thousands of CRISPR perturbations https://t.co/hUzgMdMJAx
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A bit late to this party, but this is an important read for those who are thinking about enhancer-promoter mapping. Been a pleasure watching @FulcoCharles develop this concept through the years in @jengreitz's group.
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RT @generegulation: Activity-by-Contact model of enhancer specificity from thousands of CRISPR perturbations https://t.co/bChISR02AE Enhanc…
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Activity-by-Contact model of enhancer specificity from thousands of #CRISPR perturbationFulco CP [..] Lander ES, Engreitz JM. bioRxiv. 2019-01-26. https://t.co/SAKakxiZlr "CRISPRi-FlowFISH; ABC model"
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RT @generegulation: Activity-by-Contact model of enhancer specificity from thousands of CRISPR perturbations https://t.co/bChISR02AE Enhanc…
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RT @jengreitz: Our latest is on bioRxiv: https://t.co/YFyVGJGTQ0 Q: Can we predict which enhancers regulate which genes in the human genom…
665 followers
RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
176 followers
RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
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RT @IdoAmitLab: !!! new approach to identifying enhancer-gene relationships!!! ||Activity-by-Contact model of enhancer specificity from tho…
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RT @IdoAmitLab: !!! new approach to identifying enhancer-gene relationships!!! ||Activity-by-Contact model of enhancer specificity from tho…
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RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
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RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
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RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
686 followers
RT @anshulkundaje: A must read for folks developing computational methods for enh-promoter interactions. Note how supervised ML methods tra…
187 followers
RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
531 followers
RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
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RT @RegulatoryDNA: @hms_sysbio PhD student @fulcocharles used hundreds of thousands of crispr perturbations across nearly a thousand REs to…
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RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
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RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
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RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
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RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
527 followers
RT @IdoAmitLab: !!! new approach to identifying enhancer-gene relationships!!! ||Activity-by-Contact model of enhancer specificity from tho…
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これ、データベース化されたら最高じゃん…
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RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
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RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
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Thread
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RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
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RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
41,565 followers
RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
625 followers
RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
809 followers
RT @anshulkundaje: A must read for folks developing computational methods for enh-promoter interactions. Note how supervised ML methods tra…
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RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
352 followers
Interesting new paper from our lab using CRISPRI screening to investigate enhancer-core promoter connections and specificity, lead by @FulcoCharles and @jengreitz! https://t.co/9lPK5psqfr
352 followers
RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
1,430 followers
RT @IdoAmitLab: !!! new approach to identifying enhancer-gene relationships!!! ||Activity-by-Contact model of enhancer specificity from tho…
410 followers
RT @IdoAmitLab: !!! new approach to identifying enhancer-gene relationships!!! ||Activity-by-Contact model of enhancer specificity from tho…
522 followers
RT @IdoAmitLab: !!! new approach to identifying enhancer-gene relationships!!! ||Activity-by-Contact model of enhancer specificity from tho…
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RT @jengreitz: Our latest is on bioRxiv: https://t.co/YFyVGJGTQ0 Q: Can we predict which enhancers regulate which genes in the human genom…
17,975 followers
RT @jengreitz: Our latest is on bioRxiv: https://t.co/YFyVGJGTQ0 Q: Can we predict which enhancers regulate which genes in the human genom…
441 followers
RT @IdoAmitLab: !!! new approach to identifying enhancer-gene relationships!!! ||Activity-by-Contact model of enhancer specificity from tho…
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RT @ReiterLab: Flummoxed by which regulatory elements control your gene in a particular cell type? A pretty simple model from Fulco et al i…
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Flummoxed by which regulatory elements control your gene in a particular cell type? A pretty simple model from Fulco et al incorporating element number, ATACseq/H3K27Ac marks and HiC does pretty well! https://t.co/TWoCougigZ
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RT @IdoAmitLab: !!! new approach to identifying enhancer-gene relationships!!! ||Activity-by-Contact model of enhancer specificity from tho…
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RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
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RT @CRISPR_papers: Activity-by-Contact model of enhancer specificity from thousands of CRISPR perturbations https://t.co/14JTaJQZ8T
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RT @anshulkundaje: A must read for folks developing computational methods for enh-promoter interactions. Note how supervised ML methods tra…
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RT @fulcocharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_lander @jengreitz and more! https://t.co/PbejipLDln
1,065 followers
RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
1,065 followers
RT @anshulkundaje: A must read for folks developing computational methods for enh-promoter interactions. Note how supervised ML methods tra…
803 followers
RT @anshulkundaje: A must read for folks developing computational methods for enh-promoter interactions. Note how supervised ML methods tra…
293 followers
Activity-by-Contact model of enhancer specificity from thousands of CRISPR perturbations https://t.co/pZcGM075gD
184 followers
RT @anshulkundaje: A must read for folks developing computational methods for enh-promoter interactions. Note how supervised ML methods tra…
548 followers
RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
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Pretty cool technique and model.
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RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
94 followers
RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
226 followers
RT @jengreitz: Our latest is on bioRxiv: https://t.co/YFyVGJGTQ0 Q: Can we predict which enhancers regulate which genes in the human genom…
127 followers
RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
4,690 followers
RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
317 followers
RT @jengreitz: Our latest is on bioRxiv: https://t.co/YFyVGJGTQ0 Q: Can we predict which enhancers regulate which genes in the human genom…
1,053 followers
Activity-by-Contact model of enhancer specificity from thousands of #CRISPR perturbations https://t.co/3Os7HXLzNm
188 followers
RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
981 followers
RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
2,068 followers
RT @IdoAmitLab: !!! new approach to identifying enhancer-gene relationships!!! ||Activity-by-Contact model of enhancer specificity from tho…
131 followers
RT @generegulation: Activity-by-Contact model of enhancer specificity from thousands of CRISPR perturbations https://t.co/bChISR02AE Enhanc…
125 followers
RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
426 followers
RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
311 followers
RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
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RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
6,823 followers
RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
1,379 followers
RT @anshulkundaje: A must read for folks developing computational methods for enh-promoter interactions. Note how supervised ML methods tra…
735 followers
RT @FulcoCharles: Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With @eric_…
182 followers
Totally agree. Promoter-Enh interactions are quantitative and "top" Hi-C contacts are not always PE-interactions, such as loops. ABC (DHS-based activity * contact_frequency) model looks promising! https://t.co/fk0bkcm6m8
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RT @jengreitz: Our latest is on bioRxiv: https://t.co/YFyVGJGTQ0 Q: Can we predict which enhancers regulate which genes in the human genom…
509 followers
RT @IdoAmitLab: !!! new approach to identifying enhancer-gene relationships!!! ||Activity-by-Contact model of enhancer specificity from tho…
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