RT @NavroopSingh_: All we need is for AY.1 (Delta Plus) to pick up N501Y and we might have our first Variant of High Consequence. N501Y +…

RT @rdumont99: Delta +N501Y and E484K wasn't quite the "Delta plus plus" I was originally fearing, but could potentially be worse - and cou…

Delta +N501Y and E484K wasn't quite the "Delta plus plus" I was originally fearing, but could potentially be worse - and could earn the first "variant of high consequence" https://t.co/m7fqp71ke6

RT @Daoyu15: @TheSeeker268 Rosetta does not fully recarpitulate the 501 issue on the RBD. in Rosetta, N501 and D501 have no difference in e…

RT @JosetteSchoenma: Ik heb het even nagekeken en de sequencing gegevens van de monsters van het verzorgingstehuis in België zeggen inderda…

RT @JosetteSchoenma: Ik heb het even nagekeken en de sequencing gegevens van de monsters van het verzorgingstehuis in België zeggen inderda…

RT @JosetteSchoenma: Ik heb het even nagekeken en de sequencing gegevens van de monsters van het verzorgingstehuis in België zeggen inderda…

RT @JosetteSchoenma: Ik heb het even nagekeken en de sequencing gegevens van de monsters van het verzorgingstehuis in België zeggen inderda…

RT @JosetteSchoenma: Ik heb het even nagekeken en de sequencing gegevens van de monsters van het verzorgingstehuis in België zeggen inderda…

Ik heb het even nagekeken en de sequencing gegevens van de monsters van het verzorgingstehuis in België zeggen inderdaad B.1.621 met beide spike mutaties. De K417N en de N501Y. 🤔

RT @HarrySpoelstra: "The K417N mutation had much more pronounced effect and in a combination with N501Y fully abolished the antibody effect…

@JosetteSchoenma This may explain a lot, similar to #Beta/ #Gamma https://t.co/rtkOFdRoTA

"The K417N mutation had much more pronounced effect and in a combination with N501Y fully abolished the antibody effect" Is this the problem with the #B1621 variant recently discovered in #Belgium? This certainly needs follow-up! https://t.co/CF8h4ARQfU

@Heyheydownthes1 @wecarryon2 @NewsReader604 My thought all along is that maybe we're only just exiting BC's "1st wave". The Spanish Flu pandemic came back with a vengeance after everyone thought it was beat. If we don't get to key immunization thresholds

@bitjimbog @EricTopol Superposed on temperature and social distancing are inherent transmission characteristics of a strain. Alpha's spike binding domain protein is a bit different and has a higher binding affinity to ACE2 (it is stickier)--> lower exp

RT @BWMosher: @BioTurboNick @Theresa_Chapple The plus is K417N https://t.co/zb6u9DykpV

@BioTurboNick @Theresa_Chapple The plus is K417N https://t.co/zb6u9DykpV

RT @NavroopSingh_: All we need is for AY.1 (Delta Plus) to pick up N501Y and we might have our first Variant of High Consequence. N501Y +…

RT @NavroopSingh_: All we need is for AY.1 (Delta Plus) to pick up N501Y and we might have our first Variant of High Consequence. N501Y +…

RT @NavroopSingh_: All we need is for AY.1 (Delta Plus) to pick up N501Y and we might have our first Variant of High Consequence. N501Y +…

RT @NavroopSingh_: All we need is for AY.1 (Delta Plus) to pick up N501Y and we might have our first Variant of High Consequence. N501Y +…

RT @NavroopSingh_: All we need is for AY.1 (Delta Plus) to pick up N501Y and we might have our first Variant of High Consequence. N501Y +…

All we need is for AY.1 (Delta Plus) to pick up N501Y and we might have our first Variant of High Consequence. N501Y + K417N is shown to be a very evasive combo. Add in Delta's virulence and infectiousness - https://t.co/PkkmGSDnmP

The N501Y and K417N mutations in the spike protein of SARS-CoV-2 alter the interactions with both hACE2 and human derived antibody: A Free energy of perturbation study https://t.co/icmtiYyyv3

RT @rdumont99: All we need is for AY.1 (Delta Plus) to pick up N501Y and we might have our first Variant of High Consequence. N501Y + K417…

RT @rdumont99: All we need is for AY.1 (Delta Plus) to pick up N501Y and we might have our first Variant of High Consequence. N501Y + K417…

RT @rdumont99: All we need is for AY.1 (Delta Plus) to pick up N501Y and we might have our first Variant of High Consequence. N501Y + K417…

All we need is for AY.1 (Delta Plus) to pick up N501Y and we might have our first Variant of High Consequence. N501Y + K417N is shown to be a very evasive combo. Add in Delta's virulence and infectiousness, and ... https://t.co/qhWKdzrQQt

RT @arkmedic: @dgurdasani1 Again, cases don't matter so please stop scaremongering about #covid19 disease in "school age children" This ou…

@vipintukur @JamesTGallagher I was looking at this so I could know more abt K417N. https://t.co/sHDEw9v7jh

#SARSCoV2 Se han localizado en Portugal 12 casos de la variante B.1.617.2 (variante Delta o India) que tiene la mutacion adicional en la base 417, la K417N (que también tiene la sudafricana) esta mutación permite eludir anticuerpos de forma muy eficaz h

“The K417N mutation had much more pronounced effect and in a combination with N501Y fully abolished the antibody effect” https://t.co/EGrRNS6wtP

RT @DmodosCutter: @SafeEdForAll_UK @TigressEllie @karamballes

RT @DmodosCutter: @SafeEdForAll_UK @TigressEllie @karamballes

@SafeEdForAll_UK @TigressEllie @karamballes

RT @nikkiraqs: @NHSSTAFFCOVID19 @UKActionteam https://t.co/tWrAC6jYaD

Fratev, F. (2021). The N501Y and K417N mutations in the spike protein of SARS-CoV-2 alter the interactions with both hACE2 and human derived antibody: A Free energy of perturbation study. 𝘣𝘪𝘰𝘙𝘹𝘪𝘷. https://t.co/BCGgWyiCcH.

https://t.co/lvgiqeBRli

@Lankister_bzh @Mediavenir https://t.co/mgsDhiIEWK https://t.co/VuZgPFkRRC https://t.co/SZpgxFtTbt https://t.co/ee85kwWGUx https://t.co/fhMQQP82HK https://t.co/nXsEnmiB1q https://t.co/G0yeDLjr1P

@DrEricDing And K417: "...The K417N mutation had much more pronounced effect and in a combination with N501Y fully abolished the antibody effect..." https://t.co/JCLMwTKlGk

@MauriceMartin01 https://t.co/KYsCinNNzc La conclusion concernant l'efficacité des vaccins sur les 2 variants est inquiétante.

元→https://t.co/bhTJ0FroWn

RT @vipintukur: The #K417N mutation had much more pronounced effect & in combination with #N501Y fully abolished the antibody effect!! htt…

K417N mutation had much > pronounced effect & in a combination with N501Y fully abolished the antibody effect. This may explain the observed in 🇬🇧&🇿🇦 > spread of the 🦠 but also raise an important question about the success of already availabl

The #K417N mutation had much more pronounced effect & in combination with #N501Y fully abolished the antibody effect!! https://t.co/AjF68gJA6G

RT @FreitasABR: @K_G_Andersen "The K417N mutation had much more pronounced effect and in a combination with N501Y fully abolished the antib…

RT @FreitasABR: @K_G_Andersen "The K417N mutation had much more pronounced effect and in a combination with N501Y fully abolished the antib…

"The K417N mutation had much more pronounced effect and in a combination with N501Y fully abolished the antibody effect." https://t.co/JCLMwTKlGk

@K_G_Andersen "The K417N mutation had much more pronounced effect and in a combination with N501Y fully abolished the antibody effect." https://t.co/JCLMwTKlGk

@rupert_pearse Data support delay in short term, however it could all get v interesting (medical euphemism 4 oh oh) if K417N does impair vaccine response - no compelling data one way or other yet but this is concerning: https://t.co/gRGjCCpv6i. So vaccinat

@nir_gefen לא חושב שהספיקו. נתקלתי רק במאמרי פרדיקציה (חדשים) שטוענים שיתכן ויש לN501Y ו-K417N אפיניות גבוהה יותר - בעזרת כל מיני שיטות חישוביות\פיזיקליות https://t.co/6RcMGGT8XH https://t.co/tCH8ODYbeV אם מישהו ימצא אשמח לראות (בטוח יצאו מאמרים כאלו בקרוב

RT @OrionEridanus: @DrMattMcCarthy Two independent investigations find the N501Y RBD spike protein has a higher binding affinity to hACE2.…

@CantonduJura @martialcourtet @jacquesgerberch urgent d’agir! Le Jura est en très mauvaise posture, noyer le poisson dans la marre n’est pas la solution. La rentrée c’est lundi! Des mails vous ont été adressés et sont restés sans réponse à ce jour!

@fl_laure ... de l’Imperial College de Londres. Sans compter l’augmentation très probable de la transmissibilité du virus. Charges virales plus élevées : https://t.co/9JyDJKgbex Affinités accrues pour le récepteur ACE2 : https://t.co/gYT1iyq0yG ... ⬇️

RT @Micar21Ltd: The N501Y and K417N mutations in the spike protein of SARS-CoV-2 alter the interactions with both hACE2 and human derived a…

RT @Micar21Ltd: https://t.co/2usrgcEve6 This may explain the observed in UK and South Africa more spread of the virus but also raise an imp…

https://t.co/2usrgcEve6 This may explain the observed in UK and South Africa more spread of the virus but also raise an important question about the possible human immune response and the success of already available vaccines.

The N501Y and K417N mutations in the spike protein of SARS-CoV-2 alter the interactions with both hACE2 and human derived antibody: A Free energy of perturbation study https://t.co/2usrgcEve6

@Emmanuel_microb And the acquired antibodies by all the people with lots of contacts (such as health care workers, teachers and workers) are obsolete for this mutation. Only an elimination strategy for the schools and companies can work. https://t.co/TlSkQ

@vanranstmarc De cijfers in België zullen - zoals bij elke 2 weken durende vakantie - zakken tot 27 januari. Belangrijk dat de import gestopt wordt, ja. Mr de scholen heropenen nu, is gekkenwerk. Zeker nu blijkt dat de verworven 15-30% groepsimmuniteit nut

@DrMattMcCarthy Two independent investigations find the N501Y RBD spike protein has a higher binding affinity to hACE2. No evidence that B.1.1.7 is more virulent, but there is also no evidence that it is *not* more virulent. https://t.co/xlmJXBQuJy https

RT @PaulWol83026788: @Hepworthclare @drbeen_medical Hot off the press - another pre print from Filip Fratev. In his previous work he model…

RT @ClaudeSteve6: Charges virales+importantes? https://t.co/9JyDJKgbex Meilleure affinité pour récepteur ACE2? https://t.co/gYT1iyq0yG Risq…

RT @vipintukur: The #SARSCoV2 S1 spike protein mutation #N501Y alters the protein interactions with both hACE2 and human derived antibody.…

@Hepworthclare @drbeen_medical Hot off the press - another pre print from Filip Fratev. In his previous work he modelled the N501Y mutation. This one also includes the k417N mutation found in South Africa. https://t.co/NtZfkUx7J1

RT @ClaudeSteve6: @jlgervaise @Damkyan_Omega @Sanakan00 @T_Fiolet Je ne sais pas ce que vaut ce papier mais in vitro ça semble aller dans c…

@jlgervaise @Damkyan_Omega @Sanakan00 @T_Fiolet Je ne sais pas ce que vaut ce papier mais in vitro ça semble aller dans ce sens, avec plus d'affinité sur les récepteurs ACE2 https://t.co/gYT1iyq0yG

RT @ClaudeSteve6: Charges virales+importantes? https://t.co/9JyDJKgbex Meilleure affinité pour récepteur ACE2? https://t.co/gYT1iyq0yG Risq…

RT @ClaudeSteve6: Charges virales+importantes? https://t.co/9JyDJKgbex Meilleure affinité pour récepteur ACE2? https://t.co/gYT1iyq0yG Risq…

RT @ClaudeSteve6: Charges virales+importantes? https://t.co/9JyDJKgbex Meilleure affinité pour récepteur ACE2? https://t.co/gYT1iyq0yG Risq…

Charges virales+importantes? https://t.co/9JyDJKgbex Meilleure affinité pour récepteur ACE2? https://t.co/gYT1iyq0yG Risque élevé pour l'ECDC https://t.co/qKRBGHcGoT +contagieux = +de décès https://t.co/vW7YhMH1IM On se retrouve en décembre 2020, alertes d

@DrEricDing The new variant does seem to be able to escape previous variant antibodies. What do you think? https://t.co/TeP1B4chwV https://t.co/jhYfgStaMz

@ine69206804 @rtenews Thanks to free energy perturbation (FEP) and Molecular dynamics (MD the N501Y mutation the new more infectious strain of the virus was identified . https://t.co/lWRNpvRdwP

Disse mutationer understreger behovet for en øget opmærksomhed og agtpågivenhed. Men de er ikke grund til panik. Kilde: https://t.co/ff5VtlDMRd Kilde: https://t.co/W4XJy1dG08 Kilde: https://t.co/L3X8Xpj9oA

RT @kuma_kichi_1Q63: #新型コロナウイルス SARS-CoV-2 S1スパイクタンパク質変異N501Yの“予備的研究”が公開されていた。 The SARS-CoV-2 S1 spike protein mutation N501Y alters the p…

RT @omlazo: Ese análisis es de Septiembre e iba para otro lado. Más ad hoc es el preprint de Fratev, de hace tres días, cuyo modelo también…

RT @omlazo: Ese análisis es de Septiembre e iba para otro lado. Más ad hoc es el preprint de Fratev, de hace tres días, cuyo modelo también…

RT @omlazo: Ese análisis es de Septiembre e iba para otro lado. Más ad hoc es el preprint de Fratev, de hace tres días, cuyo modelo también…

#新型コロナウイルス SARS-CoV-2 S1スパイクタンパク質変異N501Yの“予備的研究”が公開されていた。 The SARS-CoV-2 S1 spike protein mutation N501Y alters the protein interactions with both hACE2 and human derived antibody: A Free energy of perturbation study https://t.co/sYkXCIVsNJ

Ese análisis es de Septiembre e iba para otro lado. Más ad hoc es el preprint de Fratev, de hace tres días, cuyo modelo también concluye que habría mayor afinidad entre la Spike mutada en N501Y y el sitio de unión en la ACE2. https://t.co/R5dVejBiuR https:

The SARS-CoV-2 S1 spike protein mutation N501Y alters the protein interactions with both hACE2 and human derived antibody: A Free energy of perturbation study | bioRxiv https://t.co/9zUosGWdUT

RT @DoomsMost: Hmm... @AnomalousChurch Kingston, Queen’s University, Dr Gerald Evans (chair of infectious diseases). N501Y Mutation #Covid2…

RT @DoomsMost: @CDCgov @CDCemergency

RT @DoomsMost: Hmm... @AnomalousChurch Kingston, Queen’s University, Dr Gerald Evans (chair of infectious diseases). N501Y Mutation #Covid2…

RT @DoomsMost: @CDCgov @CDCemergency

@CDCgov @CDCemergency

@thelinecanada

Hmm... @AnomalousChurch Kingston, Queen’s University, Dr Gerald Evans (chair of infectious diseases). N501Y Mutation #Covid21 https://t.co/gTipXBckCp

@gonogoceo 501변이는 기존 백신이 들을 가능성에 의문을 제기 하는 논문이 나왔습니다. 언론들은 먹히는 것 처럼 번역 하던데 https://t.co/WICE3cRy6K 보면 좀..... 긍정적이진 않은 ... 아스트라 제네카 CEO도 해봐야 안다고 한게

RT @vipintukur: The #SARSCoV2 S1 spike protein mutation #N501Y alters the protein interactions with both hACE2 and human derived antibody.…

RT @Faytukss: Pre-print paper out saying that the N501Y mutation [UK variant] may significantly 'evade' a key SARS-Cov-2 antibody (STE90-C1…

RT @Faytukss: Pre-print paper out saying that the N501Y mutation [UK variant] may significantly 'evade' a key SARS-Cov-2 antibody (STE90-C1…

RT @Faytukss: Pre-print paper out saying that the N501Y mutation [UK variant] may significantly 'evade' a key SARS-Cov-2 antibody (STE90-C1…

The SARS-CoV-2 S1 spike protein mutation N501Y alters the protein interactions with both hACE2 and human derived antibody: A Free energy of perturbation study https://t.co/xOXLlKaWoz

$regn $gild $lly

RT @L0gg0l: New pre-print paper out saying the N501Y mutation may significantly evade a key SARS-Cov-2 antibody (STE90-C11) and could decre…

RT @L0gg0l: New pre-print paper out saying the N501Y mutation may significantly evade a key SARS-Cov-2 antibody (STE90-C11) and could decre…

RT @L0gg0l: New pre-print paper out saying the N501Y mutation may significantly evade a key SARS-Cov-2 antibody (STE90-C11) and could decre…

RT @L0gg0l: New pre-print paper out saying the N501Y mutation may significantly evade a key SARS-Cov-2 antibody (STE90-C11) and could decre…

RT @L0gg0l: New pre-print paper out saying the N501Y mutation may significantly evade a key SARS-Cov-2 antibody (STE90-C11) and could decre…