Wow 🤩... "resolutions down to 1 nm or better" with optical microscopy
Expansion microscopy at one nanometer resolution https://t.co/NJpsGYSqfm amazing and exciting improvements
RT @dgaboriau: Very smart workflow!
What a wonderful Triangulate Smart Ruler (TSR) tool from @_NanoTag_ ! How small is small? It took us a while to think about a target that we could use to validate our practical resolution. @FelipeOpaz_o came to the rescue with the TSR design. Story: https:
RT @MasaSomiya: 1nmスケールで生体分子が観察できるという内容のプレプリント、素人なので分からないのですがサンプルを拡張して観察する事を「1nmの”解像度”」と表現してしまうのって定義的にOKなんでしょうか？スケールバーの数字もnm刻みでちょっとやりすぎでは？と…
Very smart workflow!
ExM & SRRF combined to visualize protein shape. Amazing work by a great team. https://t.co/xgdoiEZPRQ
Alright we have a winner: ONE microscopy. Expansion fluorescence #microscopy with 1 nm resolution. When the resolution is 10x higher than the standard label —> need more nanobodies…
Saturday morning read. Sounds phantastic, and what a team!
The revolution will not be vitrified! Move over #cryoEM & #cryoET, welcome #ONE_Microscopy 😍https://t.co/dxkkqBk1bI Amazing work from @AliHShaib and the Rizzoli lab, building on concepts from @eboyden3 and @HenriquesLab. With a #GABAA receptor teaser f
Molecular #resolution adapting #SRRF & #ExM in a new method termed #ONE_Microscopy. Great work of @AliHShaib from Rizzoli´s lab. We used here #nanbodies from @_NanoTag_ as molecular rulers. Check the preprint in @biorxivpreprint here: https://t.co/cDI
😍 Holy Moly! @AliHShaib just established ONE, a method combining #ExM and #SRRF to achieve one nanometre resolution imaging on most microscopes! Figures are beyond super!! Congratulations everyone, can't wait to try it https://t.co/NIgV6zeGTj
This is looks amazing. Must read. Using ExM to get to sub-nm resolution in light micriscopy! Looks too good to be true.
Through #ONE_Microscopy, we could also image and classify molecular aggregates in cerebrospinal fluid samples from #Parkinsons Disease (PD) patients, which represents a promising new development towards an improved PD #diagnosis. #medicine Story: https://t
What happens when we combine a visionary technology concept from @eboyden3 and an innovative super-resolution fluctuation analysis from @HenriquesLab? Result: #ONE_Microscopy with ~ 1 nm or below resolution. #ONE story is available on BioRxiv: https://t.co
SRRF unlock sub-nanometer ExM!
Have you ever wondered how @Abberior STAR635P secondary antibody look like? Here is a #ONE_Microscopy single non-averaged image of the antibody Ultra-resolution for all! #ONE story is available on #BioRxiv: https://t.co/uxUZTUZeYl https://t.co/QBzVIDSy2q
#ONE_Microscopy allowed us to detect antibodies from patient sera binding the spike proteins of #SARSCoV2 viral molecules. Moreover, ONE provides enough resolution to investigate molecular complexes & even single protein shapes. Full story now availabl
#ONE_Microscopy technology allows to look into shapes of single proteins. Moreover, conformational changes undergone by the ~17 kDa protein calmodulin upon Ca2+ binding were readily observable. Full story now available on: https://t.co/uxUZTUZeYl https://t
#ONE_Microscopy technology revealed detailed nanoscale arrangements of synaptic proteins, including a quasi-regular organization of PSD95 clusters we term Retiolum. Full story now available on: https://t.co/uxUZTUZeYl https://t.co/lf4OUH2WVH
#Democratizing ultra-resolution: We have successfully applied #ONE_Microscopy to image cultured cells, tissues, viral particles, molecular complexes and even single proteins without the requirement of complex imaging machinery. Full story: https://t.co/ux
Hello world, ONE is here... I am happy to share with you a new technology —termed #ONE_Microscopy, that allows a resolution approaching ~8 Å using conventional light microscopy. @LabSauer @eboyden3 @RaduAricescu Full story: https://t.co/uxUZTUZeYl https://
Expansion microscopy at one nanometer resolution https://t.co/ZrZ9nmeDuv