All of the 'flattening the curve' talks remind me of this paper by @Luke0connor "Polygenicity of complex traits is explained by negative selection." https://t.co/IIjMBy4wVs here 'flattening' = negative selection constraining the maximum effect size
Li: Why don't common variants close to for genes have large effect sizes? Probably natural selection. C.f. "flattening" https://t.co/DVZtffNfM1 #isag2019
RT @LaramieDuncan: New work about the degree of polygenicity, for different traits. Note schizophrenia and fertility findings. https://t.…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @LaramieDuncan: New work about the degree of polygenicity, for different traits. Note schizophrenia and fertility findings. https://t.…
RT @LaramieDuncan: New work about the degree of polygenicity, for different traits. Note schizophrenia and fertility findings. https://t.…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @LaramieDuncan: New work about the degree of polygenicity, for different traits. Note schizophrenia and fertility findings. https://t.…
New work about the degree of polygenicity, for different traits. Note schizophrenia and fertility findings.
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @melindacmills: Interesting to see how our fertility traits of number of children ever born and age at first birth rank - we have some n…
RT @melindacmills: Interesting to see how our fertility traits of number of children ever born and age at first birth rank - we have some n…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @melindacmills: Interesting to see how our fertility traits of number of children ever born and age at first birth rank - we have some n…
RT @melindacmills: Interesting to see how our fertility traits of number of children ever born and age at first birth rank - we have some n…
Interesting to see how our fertility traits of number of children ever born and age at first birth rank - we have some new studies coming out - stay tuned
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
how do we determine whether a complex trait is more or less biologically tractable? i.e., how easy it is to delineate the causal chain of events leading from genotype to phenotype? polygenicity? heritability? proportion of direct vs indirect genetic effect
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
Red hair and sunburn are the least polygenic. Does this make me a genetic unicorn?
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
Interesting that polygenic scores explain so little of Red Hair variation. Clearly driven by monogenic cause. Suggests prediction of complex traits will be improved by including monogenic contributors.
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @Luke0connor: Excited to share our latest work on polygenicity and negative selection. Why are common diseases so polygenic? Our answe…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
Selection designs complex adaptations to be not overly dependent on too many mutation targets.
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
RT @dr_appie: 33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related…
33 traits ordered on polygenicity, i.e., how much of the genome contributes to their heritability. Fertility & brain related traits are most polygenic. Higher polygenicity could result from negative selection or greater biological complexity. Source
Polygenicity of complex traits is explained by negative selection https://t.co/6QhSa1BSwF
@michelnivard @cecilejanssens @swvanderlaan @WiringTheBrain This is approximately what we argued against in our preprint https://t.co/UuJ8dGUUGs I think common-SNP genetic complexity >>> biological complexity, and there are a more limited number
@itsbirdemic @critical_infras reasons to doubt omnigenic model too- Visscher paper in part replying to it, how omnigenicity is certainly not what we always see for traits like blood lipids, this ref https://t.co/0CS7eDqbQq etc. https://t.co/qLNxGxdYNK
RT @SilverVVulpes: Polygenicity of complex traits is explained by negative selection https://t.co/0CS7eDqbQq (interesting claims beyond wha…
Polygenicity of complex traits is explained by negative selection https://t.co/0CS7eDqbQq (interesting claims beyond what the title entails) The flattening concept is important, and different traits will differ on it. https://t.co/neKkJBF9ld
RT @Luke0connor: Excited to share our latest work on polygenicity and negative selection. Why are common diseases so polygenic? Our answe…
Does this lead to the prediction that (Beta_GWAS / Beta_eQTL) ~ pLI? https://t.co/SaZggK6mkx https://t.co/lZu1QtaUqP
RT @Luke0connor: Excited to share our latest work on polygenicity and negative selection. Why are common diseases so polygenic? Our answe…
@mdgallagher71 @ewanbirney @markmccarthyoxf @skathire @lpachter @leonidkruglyak @mbeisen @TriggerLoop OConnor and Price have an interesting paper on this https://t.co/d1jx9Qzwg0 Also: the rank ordered list of hits is prob. flattened by selective constraint
RT @Luke0connor: Excited to share our latest work on polygenicity and negative selection. Why are common diseases so polygenic? Our answe…
Polygenicity of complex traits is explained by negative selection https://t.co/uKoeVkZJfF
RT @Luke0connor: Excited to share our latest work on polygenicity and negative selection. Why are common diseases so polygenic? Our answe…
To-Read List: Polygenicity of complex traits is explained by negative selection https://t.co/ySUSx5DH6l
RT @Luke0connor: Excited to share our latest work on polygenicity and negative selection. Why are common diseases so polygenic? Our answe…
RT @Luke0connor: Excited to share our latest work on polygenicity and negative selection. Why are common diseases so polygenic? Our answe…
RT @Luke0connor: Excited to share our latest work on polygenicity and negative selection. Why are common diseases so polygenic? Our answe…
RT @Luke0connor: Excited to share our latest work on polygenicity and negative selection. Why are common diseases so polygenic? Our answe…
RT @Luke0connor: Excited to share our latest work on polygenicity and negative selection. Why are common diseases so polygenic? Our answe…
RT @Luke0connor: Excited to share our latest work on polygenicity and negative selection. Why are common diseases so polygenic? Our answe…
RT @Luke0connor: Excited to share our latest work on polygenicity and negative selection. Why are common diseases so polygenic? Our answe…
RT @Luke0connor: Excited to share our latest work on polygenicity and negative selection. Why are common diseases so polygenic? Our answe…
RT @Luke0connor: Excited to share our latest work on polygenicity and negative selection. Why are common diseases so polygenic? Our answe…
RT @Luke0connor: Excited to share our latest work on polygenicity and negative selection. Why are common diseases so polygenic? Our answe…
RT @Luke0connor: Excited to share our latest work on polygenicity and negative selection. Why are common diseases so polygenic? Our answe…
RT @Luke0connor: Excited to share our latest work on polygenicity and negative selection. Why are common diseases so polygenic? Our answe…
Evolution -> “polygenicity” -> diseases.
RT @eratosignis: This looks really interesting! https://t.co/N8Rg71yz8H
RT @Luke0connor: Excited to share our latest work on polygenicity and negative selection. Why are common diseases so polygenic? Our answe…
RT @Luke0connor: Excited to share our latest work on polygenicity and negative selection. Why are common diseases so polygenic? Our answe…
RT @Luke0connor: Excited to share our latest work on polygenicity and negative selection. Why are common diseases so polygenic? Our answe…
RT @Luke0connor: Excited to share our latest work on polygenicity and negative selection. Why are common diseases so polygenic? Our answe…