RT @jonathan_flint1: Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/NJ0VXcvY76
@Byrnafyrna Hey Enda, who's "Edna Byrne"? Barry Humphries will be pleased ☺ Re increased out of sample r^2 for DEP vs. information. It's still a true increase, right (for goal of DEP risk)? Even off-axis low-information data adds value https://t.co/h6Y3CN
RT @GWAS_lit: Minimal phenotyping yields GWAS hits of reduced specificity for major depression https://t.co/TpJ7aniEc9 https://t.co/KZBewv3…
RT @GWAS_lit: Minimal phenotyping yields GWAS hits of reduced specificity for major depression https://t.co/TpJ7aniEc9 https://t.co/KZBewv3…
RT @GWAS_lit: Minimal phenotyping yields GWAS hits of reduced specificity for major depression https://t.co/TpJ7aniEc9 https://t.co/KZBewv3…
Minimal phenotyping yields GWAS hits of reduced specificity for major depression https://t.co/TpJ7aniEc9 https://t.co/KZBewv3tDL
@psmaldino @JkayFlake @caseyjlaw @rmaccoun @jamesheathers @DamienFarine @babeheim @rlmcelreath @deevybee 3/3 @caina89 has a sweet paper on this actually, showing that different operationalizations of depression lead to different genetic findings. https:/
Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/6EB1lvx11Y @hitop_system
@MatthewHotopf Results of genetic analyses DO change according to how you cut the cake: https://t.co/VGFYWSc8dz
RT @jorsmo: Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/Kjv2FjKnlT
RT @GWAS_lit: Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/LsFwtbn5n9 https://t.co/HOsPzzIPDZ
RT @david_a_knowles: Great talk from @caina89 at @UCLA_CGSI showing #GWAS on relaxed definitions of depression captures substantial non-spe…
Great talk from @caina89 at @UCLA_CGSI showing #GWAS on relaxed definitions of depression captures substantial non-specific genetic signal from other psych traits https://t.co/fJevvQ9xjN
RT @pnatarajanmd: Differences in genetic associations when using self-reported major depression vs stricter definitions of major depression…
RT @caina89: Preprint update: version 2 of "Minimal phenotyping yields GWAS hits of low specificity for major depression" with @jonathan_fl…
RT @HEdenberg2: Minimal phenotyping not enough to understand genetics of complex disorders. “Reliance on results from minimal phenotyping f…
RT @HEdenberg2: Minimal phenotyping not enough to understand genetics of complex disorders. “Reliance on results from minimal phenotyping f…
RT @jorsmo: Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/Kjv2FjKnlT
RT @MathiasVSchmidt: Important paper with implications also for animal models: a few simple tests of just a couple of minutes in animals eq…
RT @MathiasVSchmidt: Important paper with implications also for animal models: a few simple tests of just a couple of minutes in animals eq…
Important paper with implications also for animal models: a few simple tests of just a couple of minutes in animals equal minimal phenotyping and are likely not of high translational value.
RT @HEdenberg2: Minimal phenotyping is not enough to truly understand genetics of complex disorders. "genetic predictors based on minimal p…
RT @GWAS_lit: Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/LsFwtbn5n9 https://t.co/HOsPzzIPDZ
RT @HEdenberg2: Minimal phenotyping is not enough to truly understand genetics of complex disorders. "genetic predictors based on minimal p…
RT @HEdenberg2: Minimal phenotyping is not enough to truly understand genetics of complex disorders. "genetic predictors based on minimal p…
RT @HEdenberg2: Minimal phenotyping not enough to understand genetics of complex disorders. “Reliance on results from minimal phenotyping f…
RT @HEdenberg2: Minimal phenotyping is not enough to truly understand genetics of complex disorders. "genetic predictors based on minimal p…
RT @HEdenberg2: Minimal phenotyping is not enough to truly understand genetics of complex disorders. "genetic predictors based on minimal p…
RT @HEdenberg2: Minimal phenotyping is not enough to truly understand genetics of complex disorders. "genetic predictors based on minimal p…
RT @HEdenberg2: Minimal phenotyping not enough to understand genetics of complex disorders. “Reliance on results from minimal phenotyping f…
RT @HEdenberg2: Minimal phenotyping is not enough to truly understand genetics of complex disorders. "genetic predictors based on minimal p…
Minimal phenotyping not enough to understand genetics of complex disorders. “Reliance on results from minimal phenotyping for MDD may thus bias views of the genetic architecture of MDD and impedes ability to identify pathways specific to MDD.” Cai et al. h
Minimal phenotyping is not enough to truly understand genetics of complex disorders. "genetic predictors based on minimal phenotyping definitions are not predictive of strictly defined MDD in independent cohorts." Cai et al. https://t.co/Wb96HrOc8F
RT @caina89: Preprint update: version 2 of "Minimal phenotyping yields GWAS hits of low specificity for major depression" with @jonathan_fl…
Important preprint! In the age of large biobanks and well powered "GWAS on demand" we still need to be thinking about how to better refine phenotypes - particularly in psych
RT @caina89: Preprint update: version 2 of "Minimal phenotyping yields GWAS hits of low specificity for major depression" with @jonathan_fl…
RT @caina89: Preprint update: version 2 of "Minimal phenotyping yields GWAS hits of low specificity for major depression" with @jonathan_fl…
RT @jorsmo: Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/Kjv2FjKnlT
RT @jorsmo: Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/Kjv2FjKnlT
A caution about relying on minimal phenotypic. Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/ynrQKHEjJD
RT @caina89: Preprint update: version 2 of "Minimal phenotyping yields GWAS hits of low specificity for major depression" with @jonathan_fl…
RT @jorsmo: Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/Kjv2FjKnlT
RT @caina89: Preprint update: version 2 of "Minimal phenotyping yields GWAS hits of low specificity for major depression" with @jonathan_fl…
RT @caina89: Preprint update: version 2 of "Minimal phenotyping yields GWAS hits of low specificity for major depression" with @jonathan_fl…
RT @jorsmo: Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/Kjv2FjKnlT
RT @caina89: Preprint update: version 2 of "Minimal phenotyping yields GWAS hits of low specificity for major depression" with @jonathan_fl…
Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/LsFwtbn5n9 https://t.co/HOsPzzIPDZ
RT @caina89: Preprint update: version 2 of "Minimal phenotyping yields GWAS hits of low specificity for major depression" with @jonathan_fl…
RT @caina89: Preprint update: version 2 of "Minimal phenotyping yields GWAS hits of low specificity for major depression" with @jonathan_fl…
RT @caina89: Preprint update: version 2 of "Minimal phenotyping yields GWAS hits of low specificity for major depression" with @jonathan_fl…
RT @caina89: Preprint update: version 2 of "Minimal phenotyping yields GWAS hits of low specificity for major depression" with @jonathan_fl…
Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/MfzQd33jD0
RT @caina89: Preprint update: version 2 of "Minimal phenotyping yields GWAS hits of low specificity for major depression" with @jonathan_fl…
RT @caina89: Preprint update: version 2 of "Minimal phenotyping yields GWAS hits of low specificity for major depression" with @jonathan_fl…
RT @caina89: Preprint update: version 2 of "Minimal phenotyping yields GWAS hits of low specificity for major depression" with @jonathan_fl…
RT @caina89: Preprint update: version 2 of "Minimal phenotyping yields GWAS hits of low specificity for major depression" with @jonathan_fl…
RT @jorsmo: Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/Kjv2FjKnlT
RT @caina89: Preprint update: version 2 of "Minimal phenotyping yields GWAS hits of low specificity for major depression" with @jonathan_fl…
Very interesting, tho I'm not sure we would expect much genetic specificity, given co-morbidity, polythetic dx criteria, phenotypic correlations with N/NE
RT @caina89: Preprint update: version 2 of "Minimal phenotyping yields GWAS hits of low specificity for major depression" with @jonathan_fl…
RT @caina89: Preprint update: version 2 of "Minimal phenotyping yields GWAS hits of low specificity for major depression" with @jonathan_fl…
RT @jorsmo: Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/Kjv2FjKnlT
On the importance of thorough phenotyping in psychiatric genetics: https://t.co/CRrkUYNPwl
RT @jorsmo: Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/Kjv2FjKnlT
Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/Kjv2FjKnlT
RT @caina89: Preprint update: version 2 of "Minimal phenotyping yields GWAS hits of low specificity for major depression" with @jonathan_fl…
This is *exactly* the argument I would use against GWAS for BMI or other crudely defined phenotypes. Sure it's easy to measure and will find you lots of GWAS hits, but for what - certainly not just body fat. Low specificity.
Differences in genetic associations when using self-reported major depression vs stricter definitions of major depression https://t.co/cBQeNebiIK @biorxiv_genetic
RT @caina89: Preprint update: version 2 of "Minimal phenotyping yields GWAS hits of low specificity for major depression" with @jonathan_fl…
RT @caina89: Preprint update: version 2 of "Minimal phenotyping yields GWAS hits of low specificity for major depression" with @jonathan_fl…
RT @caina89: Preprint update: version 2 of "Minimal phenotyping yields GWAS hits of low specificity for major depression" with @jonathan_fl…
RT @caina89: Preprint update: version 2 of "Minimal phenotyping yields GWAS hits of low specificity for major depression" with @jonathan_fl…
RT @caina89: Preprint update: version 2 of "Minimal phenotyping yields GWAS hits of low specificity for major depression" with @jonathan_fl…
RT @caina89: Preprint update: version 2 of "Minimal phenotyping yields GWAS hits of low specificity for major depression" with @jonathan_fl…
RT @caina89: Here's a recap of what we did in the previous version (see link👇) Briefly, we compared genetic architecture of different defin…
Here's a recap of what we did in the previous version (see link👇) Briefly, we compared genetic architecture of different definitions of #depression in #UKBiobank and found that genetic signal from minimal phenotyping definitions are not specific to MDD htt
Preprint update: version 2 of "Minimal phenotyping yields GWAS hits of low specificity for major depression" with @jonathan_flint1 and Ken Kendler is online! Check it out here: https://t.co/6nzTkhRRo5
RT @EikoFried: Preprint @caina89 on #depression GWAS! Minimal phenotyping: *leads to hits not specific to MDD *identifies non-specific fa…
RT @EikoFried: Preprint @caina89 on #depression GWAS! Minimal phenotyping: *leads to hits not specific to MDD *identifies non-specific fa…
RT @EikoFried: Preprint @caina89 on #depression GWAS! Minimal phenotyping: *leads to hits not specific to MDD *identifies non-specific fa…
@ODR_Psy @StuartJRitchie This is recent work by @Used_For_Glue: https://t.co/Y25yaowohw And here a preprint from @caina89: https://t.co/R4i4yuYWyG
RT @EikoFried: Preprint @caina89 on #depression GWAS! Minimal phenotyping: *leads to hits not specific to MDD *identifies non-specific fa…
Intressant kritik av strategin med minimal fenotypning i GWAS-studier av psykiatrisk genetik. Att man relativt enkelt lyckas få fram statistiskt signifikanta resultat betyder inte att metoden är fruktbar. https://t.co/uyqL9he2ne
RT @EikoFried: Preprint @caina89 on #depression GWAS! Minimal phenotyping: *leads to hits not specific to MDD *identifies non-specific fa…
Preprint @caina89 on #depression GWAS! Minimal phenotyping: *leads to hits not specific to MDD *identifies non-specific factors shared between MDD & other conditions *biases understanding of genetic architecture *limits identification of bio pathways
RT @cathrynlewis: Thanks to all speakers at our @NIHRMaudsleyBRC depression heterogeneity symposium #DepHetSymp . Links - @EikoFried's s…
RT @cathrynlewis: Thanks to all speakers at our @NIHRMaudsleyBRC depression heterogeneity symposium #DepHetSymp . Links - @EikoFried's s…
RT @cathrynlewis: Thanks to all speakers at our @NIHRMaudsleyBRC depression heterogeneity symposium #DepHetSymp . Links - @EikoFried's s…
RT @cathrynlewis: Thanks to all speakers at our @NIHRMaudsleyBRC depression heterogeneity symposium #DepHetSymp . Links - @EikoFried's s…
RT @cathrynlewis: Thanks to all speakers at our @NIHRMaudsleyBRC depression heterogeneity symposium #DepHetSymp . Links - @EikoFried's s…
Thank you for making the slides public!
RT @cathrynlewis: Thanks to all speakers at our @NIHRMaudsleyBRC depression heterogeneity symposium #DepHetSymp . Links - @EikoFried's s…
RT @cathrynlewis: Thanks to all speakers at our @NIHRMaudsleyBRC depression heterogeneity symposium #DepHetSymp . Links - @EikoFried's s…
RT @cathrynlewis: Thanks to all speakers at our @NIHRMaudsleyBRC depression heterogeneity symposium #DepHetSymp . Links - @EikoFried's s…
RT @cathrynlewis: Thanks to all speakers at our @NIHRMaudsleyBRC depression heterogeneity symposium #DepHetSymp . Links - @EikoFried's s…
RT @cathrynlewis: Thanks to all speakers at our @NIHRMaudsleyBRC depression heterogeneity symposium #DepHetSymp . Links - @EikoFried's s…
RT @cathrynlewis: Thanks to all speakers at our @NIHRMaudsleyBRC depression heterogeneity symposium #DepHetSymp . Links - @EikoFried's s…
RT @cathrynlewis: Thanks to all speakers at our @NIHRMaudsleyBRC depression heterogeneity symposium #DepHetSymp . Links - @EikoFried's s…
RT @cathrynlewis: Thanks to all speakers at our @NIHRMaudsleyBRC depression heterogeneity symposium #DepHetSymp . Links - @EikoFried's s…
RT @cathrynlewis: Thanks to all speakers at our @NIHRMaudsleyBRC depression heterogeneity symposium #DepHetSymp . Links - @EikoFried's s…