RT @cathrynlewis: Thanks to all speakers at our @NIHRMaudsleyBRC depression heterogeneity symposium #DepHetSymp . Links - @EikoFried's s…
RT @cathrynlewis: Thanks to all speakers at our @NIHRMaudsleyBRC depression heterogeneity symposium #DepHetSymp . Links - @EikoFried's s…
RT @cathrynlewis: Thanks to all speakers at our @NIHRMaudsleyBRC depression heterogeneity symposium #DepHetSymp . Links - @EikoFried's s…
RT @cathrynlewis: Thanks to all speakers at our @NIHRMaudsleyBRC depression heterogeneity symposium #DepHetSymp . Links - @EikoFried's s…
RT @cathrynlewis: Thanks to all speakers at our @NIHRMaudsleyBRC depression heterogeneity symposium #DepHetSymp . Links - @EikoFried's s…
Thanks to all speakers at our @NIHRMaudsleyBRC depression heterogeneity symposium #DepHetSymp . Links - @EikoFried's slides https://t.co/loWCybKcDf - @caina89's paper https://t.co/B2YFbVMDaS - @Used_For_Glue's 102 dep loci paper https://t.co/9iMmRJ69Z
@EikoFried @TomChivers @joannamoncrieff @matthewcobb @StuartJRitchie @cathrynlewis @jeremyfreese P.S. I also agree with your point that "depression" is a poor phenotype, particularly in large scale GWAS, and I know @jonathan_flint1 would agree - have you s
@EikoFried Have you seen this? https://t.co/72Z4tVkskT
RT @caina89: My new (and first) preprint with @jonathan_flint1, examining how using a minimal phenotyping strategy (one or two question sel…
RT @mikeweale: Valid point. Number of GWAS hits isn't everything. 2ry analyses depend on what is phenotyped. https://t.co/VhqkRMZLCo
@MuinJKhoury @biorxiv_genetic https://t.co/h6TMCelsq5 "With increasing accessibility and utilization of large biobanks and commercially collected datasets, our results are a timely warning of the consequences of lowering diagnostic specificity in genetic r
@WiringTheBrain This study is interesting: https://t.co/h6TMCelsq5 "A reliance on minimal phenotyping will bias both GWAS and secondary analysis findings towards those genetic loci shared between MDD and other conditions, limiting the potential for diseas
Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/VrZjl15rDU
RT @caina89: My new (and first) preprint with @jonathan_flint1, examining how using a minimal phenotyping strategy (one or two question sel…
Minimal phenotyping makes it possible to get the numbers needed for GWAS of complex traits, but its inaccuracies are not compensated by the large sample sizes. https://t.co/6wK1N95uaV
RT @caina89: My new (and first) preprint with @jonathan_flint1, examining how using a minimal phenotyping strategy (one or two question sel…
RT @caina89: My new (and first) preprint with @jonathan_flint1, examining how using a minimal phenotyping strategy (one or two question sel…
RT @caina89: My new (and first) preprint with @jonathan_flint1, examining how using a minimal phenotyping strategy (one or two question sel…
RT @caina89: My new (and first) preprint with @jonathan_flint1, examining how using a minimal phenotyping strategy (one or two question sel…
RT @mikeweale: Valid point. Number of GWAS hits isn't everything. 2ry analyses depend on what is phenotyped. https://t.co/VhqkRMZLCo
Valid point. Number of GWAS hits isn't everything. 2ry analyses depend on what is phenotyped. https://t.co/VhqkRMZLCo
RT @caina89: My new (and first) preprint with @jonathan_flint1, examining how using a minimal phenotyping strategy (one or two question sel…
RT @caina89: My new (and first) preprint with @jonathan_flint1, examining how using a minimal phenotyping strategy (one or two question sel…
RT @jonathan_flint1: Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/NJ0VXcvY76
RT @DABaranger: "Enrichment of heritability in CNS specific genes is found in both minimal phenotyping definitions of depression and other…
"Enrichment of heritability in CNS specific genes is found in both minimal phenotyping definitions of depression and other psychiatric conditions, but not DSM-MDD"
RT @caina89: My new (and first) preprint with @jonathan_flint1, examining how using a minimal phenotyping strategy (one or two question sel…
RT @jonathan_flint1: Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/NJ0VXcvY76
RT @caina89: My new (and first) preprint with @jonathan_flint1, examining how using a minimal phenotyping strategy (one or two question sel…
RT @caina89: My new (and first) preprint with @jonathan_flint1, examining how using a minimal phenotyping strategy (one or two question sel…
For a different perspective on this question, see: https://t.co/3ECfVq1y78
RT @caina89: My new (and first) preprint with @jonathan_flint1, examining how using a minimal phenotyping strategy (one or two question sel…
RT @caina89: My new (and first) preprint with @jonathan_flint1, examining how using a minimal phenotyping strategy (one or two question sel…
RT @caina89: My new (and first) preprint with @jonathan_flint1, examining how using a minimal phenotyping strategy (one or two question sel…
RT @caina89: My new (and first) preprint with @jonathan_flint1, examining how using a minimal phenotyping strategy (one or two question sel…
Fascinating work by @caina89 showing the influence of depth of phenotype for psychiatric disorder gene discovery
RT @caina89: My new (and first) preprint with @jonathan_flint1, examining how using a minimal phenotyping strategy (one or two question sel…
RT @jonathan_flint1: Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/NJ0VXcvY76
RT @caina89: My new (and first) preprint with @jonathan_flint1, examining how using a minimal phenotyping strategy (one or two question sel…
"..Interpretation: Using minimal phenotyping strategy for GWAS, when applied to MDD, carries significant potential risks. It primarily identifies non-specific genetic factors shared between MDD and other psychiatric conditions, .."
RT @StatGenDan: “Using minimal phenotyping strategy for GWAS, when applied to MDD,... primarily identifies non-specific genetic factors sha…
RT @caina89: My new (and first) preprint with @jonathan_flint1, examining how using a minimal phenotyping strategy (one or two question sel…
RT @caina89: My new (and first) preprint with @jonathan_flint1, examining how using a minimal phenotyping strategy (one or two question sel…
No free lunch: GWAS of MDD based on self-report of disease "...biases our view of genetic architecture of MDD, and limits our ability to identify pathways specific to MDD." An extremely important paper by @caina89 @jonathan_flint1
RT @StatGenDan: “Using minimal phenotyping strategy for GWAS, when applied to MDD,... primarily identifies non-specific genetic factors sha…
RT @caina89: My new (and first) preprint with @jonathan_flint1, examining how using a minimal phenotyping strategy (one or two question sel…
RT @caina89: My new (and first) preprint with @jonathan_flint1, examining how using a minimal phenotyping strategy (one or two question sel…
RT @caina89: My new (and first) preprint with @jonathan_flint1, examining how using a minimal phenotyping strategy (one or two question sel…
RT @caina89: My new (and first) preprint with @jonathan_flint1, examining how using a minimal phenotyping strategy (one or two question sel…
RT @jonathan_flint1: Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/NJ0VXcvY76
RT @caina89: My new (and first) preprint with @jonathan_flint1, examining how using a minimal phenotyping strategy (one or two question sel…
RT @jonathan_flint1: Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/NJ0VXcvY76
RT @caina89: My new (and first) preprint with @jonathan_flint1, examining how using a minimal phenotyping strategy (one or two question sel…
Great thread and work from @caina89 @jonathan_flint1 on the downside of minimal phenotyping for MDD genomics research. Important careful work that illustrates when it comes to phenotypes, you get what you pay for
RT @caina89: My new (and first) preprint with @jonathan_flint1, examining how using a minimal phenotyping strategy (one or two question sel…
RT @caina89: My new (and first) preprint with @jonathan_flint1, examining how using a minimal phenotyping strategy (one or two question sel…
My new (and first) preprint with @jonathan_flint1, examining how using a minimal phenotyping strategy (one or two question self-report of disease, diagnosis or treatment) affects #GWAS on #depression https://t.co/bOzKfpFHKG
RT @jonathan_flint1: Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/NJ0VXcvY76
RT @jonathan_flint1: Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/NJ0VXcvY76
RT @jonathan_flint1: Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/NJ0VXcvY76
RT @GWAS_lit: Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/3moFiF1Fnh https://t.co/C1xLqgBmvn
Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/3moFiF1Fnh https://t.co/C1xLqgBmvn
RT @jonathan_flint1: Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/NJ0VXcvY76
RT @jonathan_flint1: Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/NJ0VXcvY76
“Using minimal phenotyping strategy for GWAS, when applied to MDD,... primarily identifies non-specific genetic factors shared between MDD and other psychiatric conditions, biases our view of genetic architecture of MDD, and limits our ability to identify
RT @jonathan_flint1: Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/NJ0VXcvY76
RT @jonathan_flint1: Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/NJ0VXcvY76
Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/NJ0VXcvY76
Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/SCCra7n0Ao
Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/1l3P8MR4PQ #biorxiv_genetic
Minimal phenotyping yields GWAS hits of low specificity for major depression https://t.co/inJC94ZYFH #bioRxiv