I've tweeted about CPS1 many times An advantage to keeping my "notebook" on twitter is it's easy to find figures I've made for specific genes https://t.co/cIkT6WkleG This figure explains why CPS1 influences levels of glycine and related metabolites. https:
Clown science. 318,984 people in your study, but you choose to report at "trending" p = .12 'finding. https://t.co/dXg6NH5C1S https://t.co/EpNvnhjbv5
@cristenw The most extreme p is hidden here: https://t.co/wpOMBxpSEV Nasa Sinnott-Armstrong @ninajmars @yk_tani @aguirre404 @guhan_rv @michaelwainberg @HannaMOllila @jpirruccello @AnnaShcherbina6 @FaRodriguezMD @vintweeta @HastieTrevor @robtibshirani @samr
The strongest metabolite hit ever reported is for UGT1A1 and bilirubin (close to 1e-20000 in https://t.co/pTZPxOZM1z.) In this TWAS paper, all the genes in the region are tagged, even genes with no relation to bilirubin.
@ChrisNguyenPhD @jpirruccello @pnatarajanmd @timfrayling @minouye271 Bilirubin in UK Biobank with 400,000 people has a p-value of 1e-19,000 https://t.co/pTZPxOZM1z That's the most extreme p-value I've seen.
@jim_havrilla There are details on p20 that I think are relevant to your Q; see also Nasa's previous paper on this data set: https://t.co/rEXrUXgFLh Let me know if you have further questions.
RT @julianmutz: 'Genetics of 38 blood and urine #biomarkers in the @uk_biobank' Massive undertaking by Nasa Sinnott-Armstrong @yk_tani @ma…
@drpaternoster Or cholesterol: https://t.co/txAVt4iURF https://t.co/nMPM8fighx
And even that is not the strongest p-value ever published for SLC2A9. That honor goes to Nasa Sinnott-Armstrong and team for the 38 biomarkers paper currently in biorxiv https://t.co/OXrCAyPbvK
'Genetics of 38 blood and urine #biomarkers in the @uk_biobank' Massive undertaking by Nasa Sinnott-Armstrong @yk_tani @manuelrivascruz and colleagues - GWAS, pheWAS, PRS, MR and much more Preprint on @biorxivpreprint @biorxiv_genomic available here: ht
LIN28B has many associations, among them, circulating levels of testosterone: https://t.co/pTZPxOZM1z @manuelrivascruz @jkpritch
RT @Eric_Fauman: Here's one attempt to answer this question. For "cholesterol levels" we can reference the KEGG cholesterol metabolism map…
@manuelrivascruz @uk_biobank Here I took the 50 genes in the KEGG map and calculated the smallest distance rank to any of the 224 lead SNPs reported in https://t.co/pTZPxOZM1z. Red genes were closest to one of the 224 SNPs, orange 2nd closest, yellow 3rd
RT @Eric_Fauman: Here's one attempt to answer this question. For "cholesterol levels" we can reference the KEGG cholesterol metabolism map…
Here's one attempt to answer this question. For "cholesterol levels" we can reference the KEGG cholesterol metabolism map to id the genes we expect to see in a GWAS. Here I superimposed results from @manuelrivascruz @uk_biobank cholesterol GWAS onto KEGG
@ceclindgren At the conference I really like Nasa Sinnott-Armstrong's analysis of heritability of endophenotypes. This is something I haven't spent a lot of time on, but should look at more. https://t.co/pTZPxOZM1z
RT @Eric_Fauman: Many of the black circles, strongest local associations, are from this great paper from Nasa Sinnott-Armstrong and @manuel…
Many of the black circles, strongest local associations, are from this great paper from Nasa Sinnott-Armstrong and @manuelrivascruz https://t.co/pTZPxOZM1z. Many thanks to Nasa for recalculating exact p-values for me this week!
RT @Eric_Fauman: Thanks to Nasa Sinnott-Armstrong who gave a great presentation on the material from this preprint https://t.co/pTZPxPhmT7…
RT @Eric_Fauman: Thanks to Nasa Sinnott-Armstrong who gave a great presentation on the material from this preprint https://t.co/pTZPxPhmT7…
Thanks to Nasa Sinnott-Armstrong who gave a great presentation on the material from this preprint https://t.co/pTZPxPhmT7 I now have a numeric value for what I believe is the strongest reported p-value ever. If you geek out on extreme p-values check out m
@Luke__Ward Here's the preprint: https://t.co/pTZPxOZM1z
@LyssiotisLab @cristenw It's GOT a very strong association with liver function test (AST). neglogp of 391 in this study: https://t.co/pTZPxOZM1z
@doc_locke So much to review - just starting at the top with CPS1 over here: https://t.co/wwUTcU7m8F👇
These are the key metabolites associated with CPS1 in the @GWASCatalog + the @uk_biobank biomarker study published last month https://t.co/pTZPxOZM1z. Strongest assn ever at CPS1 reported in March by @LWittemans et al for glycine: neglogp=1631! https://t.c
今回の報告書には,最近公開した論文の草稿や共同研究に関して紹介文を書きました。詳しい内容は,bioRxiv に公開されいる pre-print をご覧ください。 バイオマーカーの遺伝学 https://t.co/z9HISFXqsC 緑内障の遺伝学 https://t.co/1CQCOkp015 大規模データ向け Lasso 回帰 https://t.co/gSfN9Bwu14
RT @KKuchenbaecker: Key points from molPsy journal club: Genetics of 38 blood and urine biomarkers https://t.co/WosZ6ykk6I -good overview…
RT @KKuchenbaecker: Key points from molPsy journal club: Genetics of 38 blood and urine biomarkers https://t.co/WosZ6ykk6I -good overview…
RT @KKuchenbaecker: Key points from molPsy journal club: Genetics of 38 blood and urine biomarkers https://t.co/WosZ6ykk6I -good overview…
RT @KKuchenbaecker: Key points from molPsy journal club: Genetics of 38 blood and urine biomarkers https://t.co/WosZ6ykk6I -good overview…
Key points from molPsy journal club: Genetics of 38 blood and urine biomarkers https://t.co/WosZ6ykk6I -good overview of all the things you can do with GWAS data -not clear what key questions are addressed and what is novel -claim of the project rather t
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
Genetics of 38 blood and urine biomarkers in the UK Biobank https://t.co/Wi6UQLK38s
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @GWAS_lit: Genetics of 38 blood and urine biomarkers in the UK Biobank https://t.co/cMRwnb3dNg https://t.co/cKvkIaMRWV
RT @biorxiv_genetic: Genetics of 38 blood and urine biomarkers in the UK Biobank https://t.co/cHsHzbQE6l #biorxiv_genetic
RT @GWAS_lit: Genetics of 38 blood and urine biomarkers in the UK Biobank https://t.co/cMRwnb3dNg https://t.co/cKvkIaMRWV
That was fast! New pre-print on genetics of blood/urine biomarkers in UK Biobank. https://t.co/DPsszymWWx
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @GWAS_lit: Genetics of 38 blood and urine biomarkers in the UK Biobank https://t.co/cMRwnb3dNg https://t.co/cKvkIaMRWV
RT @biorxiv_genetic: Genetics of 38 blood and urine biomarkers in the UK Biobank https://t.co/cHsHzbQE6l #biorxiv_genetic
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @biorxiv_genetic: Genetics of 38 blood and urine biomarkers in the UK Biobank https://t.co/cHsHzbQE6l #biorxiv_genetic
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @biorxiv_genetic: Genetics of 38 blood and urine biomarkers in the UK Biobank https://t.co/cHsHzbQE6l #biorxiv_genetic
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
Genetics of 38 blood and urine biomarkers in the UK Biobank https://t.co/cMRwnb3dNg https://t.co/cKvkIaMRWV
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
Genetics of 38 blood and urine biomarkers in the UK #Biobank @biorxivpreprint https://t.co/gOY3xMgwQP
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @a_husby: Really relevant clinical study by Nasa Sinnott-Armstrong, @yk_tani , @manuelrivascruz and others. This approach will meet the…
RT @a_husby: Really relevant clinical study by Nasa Sinnott-Armstrong, @yk_tani , @manuelrivascruz and others. This approach will meet the…
Really relevant clinical study by Nasa Sinnott-Armstrong, @yk_tani , @manuelrivascruz and others. This approach will meet the clinical world soon!
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @biorxiv_genetic: Genetics of 38 blood and urine biomarkers in the UK Biobank https://t.co/cHsHzbQE6l #biorxiv_genetic
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @paolabronson: GWAS of Lab Tests in UK Biobank/FinnGen https://t.co/wBeq9PSUEJ
GWAS of Lab Tests in UK Biobank/FinnGen
Wow! Congrats Prof. Manuel!
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @biorxiv_genetic: Genetics of 38 blood and urine biomarkers in the UK Biobank https://t.co/cHsHzbQE6l #biorxiv_genetic
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @guhan_rv: 🤘🏽🤘🏽 https://t.co/cQgqkzvSu4
Genetics of 38 blood and urine biomarkers in the UK Biobank https://t.co/7MIu00XOW4
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @biorxiv_genetic: Genetics of 38 blood and urine biomarkers in the UK Biobank https://t.co/cHsHzbQE6l #biorxiv_genetic
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @biorxiv_genetic: Genetics of 38 blood and urine biomarkers in the UK Biobank https://t.co/cHsHzbQE6l #biorxiv_genetic
RT @biorxiv_genetic: Genetics of 38 blood and urine biomarkers in the UK Biobank https://t.co/cHsHzbQE6l #biorxiv_genetic
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @biorxiv_genetic: Genetics of 38 blood and urine biomarkers in the UK Biobank https://t.co/cHsHzbQE6l #biorxiv_genetic
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @biorxivpreprint: Genetics of 38 blood and urine biomarkers in the UK Biobank https://t.co/gnmy59bu0m #bioRxiv
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @biorxiv_genetic: Genetics of 38 blood and urine biomarkers in the UK Biobank https://t.co/cHsHzbQE6l #biorxiv_genetic
RT @biorxiv_genetic: Genetics of 38 blood and urine biomarkers in the UK Biobank https://t.co/cHsHzbQE6l #biorxiv_genetic
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @biorxiv_genetic: Genetics of 38 blood and urine biomarkers in the UK Biobank https://t.co/cHsHzbQE6l #biorxiv_genetic
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…
RT @manuelrivascruz: Thrilled to see our paper "Genetics of 38 blood and urine biomarkers in the UK Biobank" on Biorxiv. Great collaborat…