RT @JSheltzer: Recently, this remarkable paper went up on @biorxivpreprint – the authors wrote that CRISPR-induced null mutations trigger a…
RT @JSheltzer: Recently, this remarkable paper went up on @biorxivpreprint – the authors wrote that CRISPR-induced null mutations trigger a…
RT @JSheltzer: Recently, this remarkable paper went up on @biorxivpreprint – the authors wrote that CRISPR-induced null mutations trigger a…
RT @JSheltzer: Recently, this remarkable paper went up on @biorxivpreprint – the authors wrote that CRISPR-induced null mutations trigger a…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Recently, this remarkable paper went up on @biorxivpreprint – the authors wrote that CRISPR-induced null mutations trigger a…
RT @JSheltzer: Recently, this remarkable paper went up on @biorxivpreprint – the authors wrote that CRISPR-induced null mutations trigger a…
RT @JSheltzer: Recently, this remarkable paper went up on @biorxivpreprint – the authors wrote that CRISPR-induced null mutations trigger a…
RT @JSheltzer: Recently, this remarkable paper went up on @biorxivpreprint – the authors wrote that CRISPR-induced null mutations trigger a…
RT @JSheltzer: Recently, this remarkable paper went up on @biorxivpreprint – the authors wrote that CRISPR-induced null mutations trigger a…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Recently, this remarkable paper went up on @biorxivpreprint – the authors wrote that CRISPR-induced null mutations trigger a…
RT @JSheltzer: Recently, this remarkable paper went up on @biorxivpreprint – the authors wrote that CRISPR-induced null mutations trigger a…
RT @JSheltzer: Recently, this remarkable paper went up on @biorxivpreprint – the authors wrote that CRISPR-induced null mutations trigger a…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Recently, this remarkable paper went up on @biorxivpreprint – the authors wrote that CRISPR-induced null mutations trigger a…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Recently, this remarkable paper went up on @biorxivpreprint – the authors wrote that CRISPR-induced null mutations trigger a…
RT @JSheltzer: Recently, this remarkable paper went up on @biorxivpreprint – the authors wrote that CRISPR-induced null mutations trigger a…
Recently, this remarkable paper went up on @biorxivpreprint – the authors wrote that CRISPR-induced null mutations trigger a pervasive up-regulation of homologs of the deleted gene. It has huge implications for CRISPR technology as well as our understandin
We had @RW_Naylor take us through this for our lab meeting today. It looks like pretty important stuff (and has some #ECM #adhesionproteins as candidates 😀) Genetic compensation is triggered by mutant mRNA degradation https://t.co/UGhADOJjxQ https://t.co/
Genetic compensation is triggered by mutant mRNA degradation https://t.co/2aNAYTz2rm
RT @MohamedBrolosy: (2) My poster was on our recent study on genetic compensation and how to effectively design mutant alleles that can unm…
(2) My poster was on our recent study on genetic compensation and how to effectively design mutant alleles that can unmask hidden phenotypes. You can find it here on bioRxiv: https://t.co/x74WkpjoOR
RT @MohamedBrolosy: Heading to the Lindau Nobel laureate meeting! Super excited! Will be also presenting a poster, drop by if you want to k…
RT @MohamedBrolosy: Heading to the Lindau Nobel laureate meeting! Super excited! Will be also presenting a poster, drop by if you want to k…
Heading to the Lindau Nobel laureate meeting! Super excited! Will be also presenting a poster, drop by if you want to know more about genetic compensation and how to effectively design mutant alleles that unmask hidden phenotypes: https://t.co/x74WkpjoOR @
Genetic compensation is triggered by mutant mRNA degradation https://t.co/ZQnVG1b7cs
mutant mRNA는 뭐가 인지하는지? Genetic compensation is triggered by mutant mRNA degradation https://t.co/L2gyj9gfou
RT @RW_Naylor: Preprint from the Stainier lab suggesting genetic compensation is triggered by mutant mRNA degradation https://t.co/zWcKSWu5…
Preprint from the Stainier lab suggesting genetic compensation is triggered by mutant mRNA degradation https://t.co/zWcKSWu5fx
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @ewbank_lab: This are indeed remarkable observations. It is equally arresting that the news about this preprint has been re-tweeted hund…
RT @ewbank_lab: This are indeed remarkable observations. It is equally arresting that the news about this preprint has been re-tweeted hund…
This are indeed remarkable observations. It is equally arresting that the news about this preprint has been re-tweeted hundreds of times, potentially reaching hundreds of thousands of readers in a couple of weeks: #preprintpower https://t.co/wtYHsw4Nyb
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @DavidMorgens: Interpretation of #CRISPR is becoming more complicated (maybe): CRISPR-induced mRNA degradation causing transcriptional c…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @jsmenet: That will change the interpretation of some previously published papers... https://t.co/TAHZWSTRil
That will change the interpretation of some previously published papers... https://t.co/TAHZWSTRil
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @mnitabach: This is HUGE! https://t.co/yUTYZpoxIE
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @mnitabach: This is HUGE! https://t.co/yUTYZpoxIE
This is HUGE! https://t.co/yUTYZpoxIE
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @SchuhLab: Acute protein degradation by Trim-Away is one way to work around knockout "compensation" by up-regulation of homologous genes…
RT @DavidMorgens: Interpretation of #CRISPR is becoming more complicated (maybe): CRISPR-induced mRNA degradation causing transcriptional c…
RT @SchuhLab: Acute protein degradation by Trim-Away is one way to work around knockout "compensation" by up-regulation of homologous genes…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
One of the many issues associated with CRISPR @JSheltzer Thanks for the breakdown, we hope to cover this as well in our siTOOLs blog https://t.co/OdyjaFyMyH https://t.co/LjY2Z6HicJ
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
Great discussion on complexity of CRISPR screen hits from @DavidMorgens, who is a total expert in the field (maybe I’m biased) https://t.co/fwwfMibcnv
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
Interpretation of #CRISPR is becoming more complicated (maybe): CRISPR-induced mRNA degradation causing transcriptional compensation of homologs https://t.co/W3AuDMPqy0 and relative but not absolute copy number determining the toxicity of CRISPR DSBs http
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
CRISPR KO mutations trigger upregulation of related genes expanding the role of RNA surveillance to buffering against NMD mutations. https://t.co/BJnF9DHp7w
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @SchuhLab: Acute protein degradation by Trim-Away is one way to work around knockout "compensation" by up-regulation of homologous genes…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @MohamedBrolosy: The mRNA surveillance machinery is amazing: not only does it protect the cell from translating defective transcripts, b…
RT @miketadross: Every causal experiment is a race between the desired effect of a manipulation and the unintended ripple effects, which gr…
RT @SchuhLab: Acute protein degradation by Trim-Away is one way to work around knockout "compensation" by up-regulation of homologous genes…
Genetic compensation is triggered by mutant mRNA degradation #CRISPR https://t.co/9jkn0vgDCa
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…