RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @SchuhLab: Acute protein degradation by Trim-Away is one way to work around knockout "compensation" by up-regulation of homologous genes…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @c_braendle: Genetic compensation is triggered by mutant mRNA degradation https://t.co/ZDwOD3twWx
New publication on the mechanism of genetic compensation by Didier Stanier's group at MPI Bad Nauheim. Read preprint: Genetic compensation is triggered by mutant mRNA degradation at https://t.co/IqFgHdNhSb and siTOOL's blogpost on their first paper at http
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @c_braendle: Genetic compensation is triggered by mutant mRNA degradation https://t.co/ZDwOD3twWx
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
Fascinating read: KO leading to mRNA decay leads to compensation from homologous genes.. https://t.co/Q3577J6js7
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
Every causal experiment is a race between the desired effect of a manipulation and the unintended ripple effects, which grow in complexity over time. #WeNeedFasterManipulations https://t.co/josu0MGusw
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
The molgula chordates that we work with are transcribing many pseudogenes, but no genome duplication! https://t.co/rTOGtIu0e7
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
Genetic compensation is triggered by mutant mRNA degradation https://t.co/y7zvwTuxKi
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
whoa.... https://t.co/Wup2ccstun
RT @ShorterLab: Genetic compensation is triggered by mutant mRNA degradation https://t.co/g1hx0ARxzi
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @SchuhLab: Acute protein degradation by Trim-Away is one way to work around knockout "compensation" by up-regulation of homologous genes…
Interesting thread on mechanisms of compensation upon CRISPR deletions https://t.co/oKBHj37cLP
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @SchuhLab: Acute protein degradation by Trim-Away is one way to work around knockout "compensation" by up-regulation of homologous genes…
RT @AaronJonScott: ICYMI: Great thread and sub-threads discussing the recent @biorxivpreprint from @GiraldezLab and Stainier Lab, regardi…
RT @SchuhLab: Acute protein degradation by Trim-Away is one way to work around knockout "compensation" by up-regulation of homologous genes…
ICYMI: Great thread and sub-threads discussing the recent @biorxivpreprint from @GiraldezLab and Stainier Lab, regarding mutant mRNA degradation being the trigger for genetic compensation. Some thoughts from @JSheltzer and responses from first author @M
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @SchuhLab: Acute protein degradation by Trim-Away is one way to work around knockout "compensation" by up-regulation of homologous genes…
RT @MohamedBrolosy: The mRNA surveillance machinery is amazing: not only does it protect the cell from translating defective transcripts, b…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
Genetic compensation is triggered by mutant mRNA degradation https://t.co/enXePuhzsS
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @SchuhLab: Acute protein degradation by Trim-Away is one way to work around knockout "compensation" by up-regulation of homologous genes…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @SchuhLab: Acute protein degradation by Trim-Away is one way to work around knockout "compensation" by up-regulation of homologous genes…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @SchuhLab: Acute protein degradation by Trim-Away is one way to work around knockout "compensation" by up-regulation of homologous genes…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @SchuhLab: Acute protein degradation by Trim-Away is one way to work around knockout "compensation" by up-regulation of homologous genes…
Interesting implications for CRISPR screening companies looking for new cancer dependencies, human KO project, many other studies/companies too. Thoughts from @JohnDoench on screening or @dgmacarthur re human KO? https://t.co/za0FdieLvZ
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @SchuhLab: Acute protein degradation by Trim-Away is one way to work around knockout "compensation" by up-regulation of homologous genes…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
Worth a look if you're using CRISP. https://t.co/ejD99ry7kn
Acute protein degradation by Trim-Away is one way to work around knockout "compensation" by up-regulation of homologous genes as reported in this interesting study by Stainier and colleagues. More info on #TrimAway: https://t.co/wXb4l03u6g https://t.co/Q11
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…