RT @cshperspectives: Thread - the critical take-home is in the penultimate tweet ;-) https://t.co/BJAjPcRC8v
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
One reason why we need to systematically study genetic interactions #CRISPR #RNAi https://t.co/dV5rFF2I8h
Genetic compensation is triggered by mutant mRNA degradation https://t.co/RplyvEj4RL
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
Not surprising that this paper is on mostly zebrafish from a zf lab... zf have ohnologues galore! Compensation used to be the bane of zf researchers lives. The little fish is so useful. https://t.co/VYDeF3snXu
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @ShorterLab: Genetic compensation is triggered by mutant mRNA degradation https://t.co/g1hx0ARxzi
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @biorxivpreprint: Genetic compensation is triggered by mutant mRNA degradation https://t.co/HFHDtTqtDs #bioRxiv
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
Genetic compensation is triggered by mutant mRNA degradation https://t.co/g1hx0ARxzi
RT @RGUNAGE: Genetic compensation is triggered by mutant mRNA degradation | bioRxiv https://t.co/cE5qiMzUCu
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
It's a bit surprising that people in the #CRISPR field have not paid much attention to these compensatory back up pathways.... Evidence exist for many #DNA repair gene knock-outs in pre-CRISPR era... https://t.co/h332bPCrfO
Very cool preprint from Didier Stanier & @GiraldezLab. Can't wait to see how these NMD products are getting targeted and what they do to the epigenome... https://t.co/ojvigP5fDi
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @cshperspectives: Thread - the critical take-home is in the penultimate tweet ;-) https://t.co/BJAjPcRC8v
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @iscotthsc: Very interesting stuff from the Stainier and Giraldez labs! Genetic compensation is triggered by mutant mRNA degradation ht…
Oh look it's a paper from Didier Stainier's lab where they're trying to republish essentially the same paper they published in 2015: https://t.co/2hZTt8XEkz
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
Genetic compensation is triggered by mutant mRNA degradation https://t.co/ZhRY6OZl36
RT @cshperspectives: Thread - the critical take-home is in the penultimate tweet ;-) https://t.co/BJAjPcRC8v
RT @JSheltzer: Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells t…
RT @cshperspectives: Thread - the critical take-home is in the penultimate tweet ;-) https://t.co/BJAjPcRC8v
Thread - the critical take-home is in the penultimate tweet ;-) https://t.co/BJAjPcRC8v
Fascinating paper. Knockout mutations that cause mRNA decay trigger the up-regulation of homologous genes, allowing cells to “compensate” for the LOF alteration. People who do CRISPR experiments will have to wrestle with these findings. Some thoughts… h
RT @iscotthsc: Very interesting stuff from the Stainier and Giraldez labs! Genetic compensation is triggered by mutant mRNA degradation ht…
Genetic compensation is triggered by mutant mRNA degradation | bioRxiv https://t.co/cE5qiMzUCu
RT @grzechnik_pawel: Beware of compensation effects! https://t.co/qbGrIylhh4
RT @iscotthsc: Very interesting stuff from the Stainier and Giraldez labs! Genetic compensation is triggered by mutant mRNA degradation ht…
RT @iscotthsc: Very interesting stuff from the Stainier and Giraldez labs! Genetic compensation is triggered by mutant mRNA degradation ht…
RT @DanTGrimes: Some new mechanistic insights into "genetic compensation" here from the Stainier lab. Among other things, this helps us und…
RT @iscotthsc: Very interesting stuff from the Stainier and Giraldez labs! Genetic compensation is triggered by mutant mRNA degradation ht…
Genetic compensation is triggered by mutant mRNA degradation https://t.co/gmIT8vOetR
RT @benoitbruneau: Great. Redo all KO mice. Thanks Obama! https://t.co/ex6FhGVH24
RT @iscotthsc: Very interesting stuff from the Stainier and Giraldez labs! Genetic compensation is triggered by mutant mRNA degradation ht…
Genetic compensation: now they got the mechanism! Beautiful work! https://t.co/YC67fuV43f
RT @benoitbruneau: Great. Redo all KO mice. Thanks Obama! https://t.co/ex6FhGVH24
RT @GiraldezLab: Genetic compensation depends on the NMD pathway and UPF1 https://t.co/zZFrjmOAFu
RT @GoreAniket: Genetic compensation is triggered by mutant mRNA degradation work from the Stainier and @GiraldezLab @biorxivpreprint http…
RT @GoreAniket: Genetic compensation is triggered by mutant mRNA degradation work from the Stainier and @GiraldezLab @biorxivpreprint http…
RT @iscotthsc: Very interesting stuff from the Stainier and Giraldez labs! Genetic compensation is triggered by mutant mRNA degradation ht…
Added to the reading list for @Lim_Labo https://t.co/zT3sSlSiOX
Watch the transcriptional “output” of your KO alleles - mRNA degradation compensation phenotypes can lead to major transcriptome perturbation, which is absent when knock-out does not make a transcript! Via @iscotthsc https://t.co/kVmhalWO2r
Genetic compensation is triggered by mutant mRNA degradation https://t.co/ZDwOD3twWx
RT @iscotthsc: Very interesting stuff from the Stainier and Giraldez labs! Genetic compensation is triggered by mutant mRNA degradation ht…
RT @biorxiv_genetic: Genetic compensation is triggered by mutant mRNA degradation https://t.co/v6jKdmgQid #biorxiv_genetic
Need to rethink how we make KOs... Genetic compensation is triggered by mutant mRNA degradation https://t.co/cksBJdp6qs
More evidence that KOs are not always gold standards to understand gene function Genetic compensation is triggered by mutant mRNA degradation https://t.co/S9mWWrcr1M