@AlicePopejoy @BarrySlavchic @Nature Martin (2019), highlighting the fact most Genome Wide Association Studies are from Europeans. This may reduce the effectiveness of polygenic risk scores for other populations. Ultimately, it would be ideal to have studi
@punter05 @raruma @emilynordmann @DrGBuckingham Eg. Martin (2019), the fact most Genome Wide Association Studies are from Europeans is an issue as there are allele frequency differences across populations. This may reduce the effectiveness of polygenic ris
@thesptrans This has a practical significance as seen in the limitations on biomedical research with most studies featuring Europeans. https://t.co/oT7U3z67YM https://t.co/V8rHSLf7Wh
RT @Rafal_M: A lot of background reading around population specificity of PRS can be achieved by looking at work from Alicia Martin et al.,…
@OneSpeciesReal @DC9Kpromo @osymandus @drjanaway @JohnCleese For starters there are correlated differences in the frequencies of gene variants across groups. Hence the clusters and why the fact most GWAS samples are from Europeans is a problem for biomedic
@haemohobgoblin @AdamRutherford @JohnCleese Not saying they are significantly different, but it's also incorrect to state that the groups are biologically meaningless. Gene frequencies vary by group. Which is why there are calls for more diverse GWAS sampl
@amarlevine @hbdchick There's a fair bit on differences by genetic ancestry groups: https://t.co/4jecm0tvz2, https://t.co/0AwH0EIL2J, https://t.co/V4FwOeonqh. Also https://t.co/J93tpu1S7G show big difference for the education score across groups.
Inclusion goes beyond age and gender #Inclusion #Diversity #Geneticdata Current clinical use of polygenic scores will risk exacerbating health disparities https://t.co/W7WmEAPhtb
RT @Biorealism: @Pinkerite1 @Glossophiliac75 @DefenderWhaman @Steve_Sailer Geographic ancestry is usually easy to infer from appearance. Yo…
@Pinkerite1 @Glossophiliac75 @DefenderWhaman @Steve_Sailer Geographic ancestry is usually easy to infer from appearance. Your suggestion that they are biologically meaningless is contradicted the calls for more diverse GWAS. https://t.co/cLdoLLzbTx https:/
@MarylynRitchie : I was literally on my soapbox about this issue the other day in a meeting with Shefali. "Current clinical use of polygenic scores will risk exacerbating health disparities" https://t.co/kucAcdYdEH - article now in @NatureGenet
The bad: currently low generalizability to most of the world (WEIRD samples!) see @genetisaur Martin 2018 https://t.co/P5wkID7D5U Lack of understanding of what PGSs actually mean + ecological fallacy! https://t.co/g6s0JEF2I3
RT @hsdash: @mete_civelek I love this one from @genetisaur. https://t.co/LDz1kozoUM https://t.co/Y8W0tf5Nhe
RT @hsdash: @mete_civelek I love this one from @genetisaur. https://t.co/LDz1kozoUM https://t.co/Y8W0tf5Nhe
RT @hsdash: @mete_civelek I love this one from @genetisaur. https://t.co/LDz1kozoUM https://t.co/Y8W0tf5Nhe
RT @hsdash: @mete_civelek I love this one from @genetisaur. https://t.co/LDz1kozoUM https://t.co/Y8W0tf5Nhe
RT @hsdash: @mete_civelek I love this one from @genetisaur. https://t.co/LDz1kozoUM https://t.co/Y8W0tf5Nhe
@mete_civelek I love this one from @genetisaur. https://t.co/LDz1kozoUM https://t.co/Y8W0tf5Nhe
RT @briandavidearp: Current clinical use of polygenic scores will risk exacerbating health disparities | bioRxiv https://t.co/JhxIBPL9gs
RT @briandavidearp: Current clinical use of polygenic scores will risk exacerbating health disparities | bioRxiv https://t.co/JhxIBPL9gs
RT briandavidearp: Current clinical use of polygenic scores will risk exacerbating health disparities | bioRxiv https://t.co/o71ubpQZNh
Current clinical use of polygenic scores will risk exacerbating health disparities | bioRxiv https://t.co/JhxIBPL9gs
RT @dccc_phd: @saralpulit Relevant reading on the topic by @genetisaur for folks interested in learning more: https://t.co/UnhcX9w05L
@saralpulit Relevant reading on the topic by @genetisaur for folks interested in learning more: https://t.co/UnhcX9w05L
Current clinical use of polygenic scores will risk exacerbating health disparities https://t.co/FOA3THdIwA #genomics #GWAS
@Scientific_Bird @amy_harmon @thessgac @DPosthu -Good articles clarifying these issues: https://t.co/SBG8V1Z9uC https://t.co/THtKrrpEzK https://t.co/cU8YNpzCJi
Current clinical use of polygenic scores will risk exacerbating health disparities https://t.co/2V8zIJ4QxW
RT @GWAS_lit: Current clinical use of polygenic scores will risk exacerbating health disparities https://t.co/TJ64g5gqnh https://t.co/90Zbj…
RT @GWAS_lit: Current clinical use of polygenic scores will risk exacerbating health disparities https://t.co/TJ64g5gqnh https://t.co/90Zbj…
RT @GWAS_lit: Current clinical use of polygenic scores will risk exacerbating health disparities https://t.co/TJ64g5gqnh https://t.co/90Zbj…
.@bioRxivpreprint cautions that current clinical use of #polygenic scores risk exacerbating #disparities. “We must prioritize greater diversity in genetic studies & public dissemination of summary statistics to ensure that disparities are not increased
The predictive values of PRS for most traits are poorer in non-European populations, indeed. The more immediately salient issue is whether the predictive values of PRS for the majority of complex diseases are clinically useful yet in any populations.... ht
RT @GWAS_lit: Current clinical use of polygenic scores will risk exacerbating health disparities https://t.co/TJ64g5gqnh https://t.co/90Zbj…
RT @GWAS_lit: Current clinical use of polygenic scores will risk exacerbating health disparities https://t.co/TJ64g5gqnh https://t.co/90Zbj…
Polygenic risk scores can worsen health disparities: "Unlike clinical biomarkers and prescription drugs... clinical uses of PRS today would systematically afford greater improvement to European descent populations." Via @biorxiv_genetic https://t.co/BAGN1u
RT @GWAS_lit: Current clinical use of polygenic scores will risk exacerbating health disparities https://t.co/TJ64g5gqnh https://t.co/90Zbj…
RT @GWAS_lit: Current clinical use of polygenic scores will risk exacerbating health disparities https://t.co/TJ64g5gqnh https://t.co/90Zbj…
RT @GWAS_lit: Current clinical use of polygenic scores will risk exacerbating health disparities https://t.co/TJ64g5gqnh https://t.co/90Zbj…
RT @GWAS_lit: Current clinical use of polygenic scores will risk exacerbating health disparities https://t.co/TJ64g5gqnh https://t.co/90Zbj…
RT @GWAS_lit: Current clinical use of polygenic scores will risk exacerbating health disparities https://t.co/TJ64g5gqnh https://t.co/90Zbj…
RT @GWAS_lit: Current clinical use of polygenic scores will risk exacerbating health disparities https://t.co/TJ64g5gqnh https://t.co/90Zbj…
RT @GWAS_lit: Current clinical use of polygenic scores will risk exacerbating health disparities https://t.co/TJ64g5gqnh https://t.co/90Zbj…
RT @GWAS_lit: Current clinical use of polygenic scores will risk exacerbating health disparities https://t.co/TJ64g5gqnh https://t.co/90Zbj…
RT @GWAS_lit: Current clinical use of polygenic scores will risk exacerbating health disparities https://t.co/TJ64g5gqnh https://t.co/90Zbj…
RT @GWAS_lit: Current clinical use of polygenic scores will risk exacerbating health disparities https://t.co/TJ64g5gqnh https://t.co/90Zbj…
Current clinical use of polygenic scores will risk exacerbating health disparities https://t.co/TJ64g5gqnh https://t.co/90ZbjR4u3Z
RT @Kate_Sci: Worth a read @MattHancock before you rollout NHS DTC genetic testing!!! https://t.co/C5mrtxVytJ
Worth a read @MattHancock before you rollout NHS DTC genetic testing!!! https://t.co/C5mrtxVytJ
@RoyAFrye1 @smaceachern2 @CathrynTownsend @amy_harmon dude... those data are meaningless. the iq measures are from noted white supremacist richard lynn (notice lack of cite). even if iq accurate/meaningful, the pgs meaningless https://t.co/dpXyfIJAD3. piff
RT @genetisaur: I'm excited to share this perspective with @dalygene, @bmneale, @masakanai, and RIKEN colleagues on the high potential for…
RT @genetisaur: I'm excited to share this perspective with @dalygene, @bmneale, @masakanai, and RIKEN colleagues on the high potential for…
RT @genetisaur: I'm excited to share this perspective with @dalygene, @bmneale, @masakanai, and RIKEN colleagues on the high potential for…
RT @genetisaur: Update! A revised version of our preprint is up now: https://t.co/vTsqH4Hyo4. Biggest changes: we compare polygenic risk sc…
RT @genetisaur: Update! A revised version of our preprint is up now: https://t.co/vTsqH4Hyo4. Biggest changes: we compare polygenic risk sc…
RT @genetisaur: I'm excited to share this perspective with @dalygene, @bmneale, @masakanai, and RIKEN colleagues on the high potential for…
RT @genetisaur: Update! A revised version of our preprint is up now: https://t.co/vTsqH4Hyo4. Biggest changes: we compare polygenic risk sc…
RT @genetisaur: Update! A revised version of our preprint is up now: https://t.co/vTsqH4Hyo4. Biggest changes: we compare polygenic risk sc…
RT @genetisaur: Update! A revised version of our preprint is up now: https://t.co/vTsqH4Hyo4. Biggest changes: we compare polygenic risk sc…
Hidden 'risk' in #polygenic scores: clinical use today could exacerbate health disparities https://t.co/93U21D6TVi #meded #gme #cme #prs #pm101 @genetisaur
RT @genetisaur: Update! A revised version of our preprint is up now: https://t.co/vTsqH4Hyo4. Biggest changes: we compare polygenic risk sc…
RT @genetisaur: Update! A revised version of our preprint is up now: https://t.co/vTsqH4Hyo4. Biggest changes: we compare polygenic risk sc…
Polygenic risk scores perform better in European populations, with prediction accuracy reduced by approximately 2-5 fold in East Asian and African descent populations. Via @biorxiv_genetic #disparities https://t.co/JcnZAORPnG https://t.co/EnXludQFxh
RT @GWAS_lit: Hidden 'risk' in polygenic scores: clinical use today could exacerbate health disparities https://t.co/mwRxs1P3Gx https://t.c…
RT @genetisaur: Update! A revised version of our preprint is up now: https://t.co/vTsqH4Hyo4. Biggest changes: we compare polygenic risk sc…
RT @GWAS_lit: Hidden 'risk' in polygenic scores: clinical use today could exacerbate health disparities https://t.co/mwRxs1P3Gx https://t.c…
RT @genetisaur: Update! A revised version of our preprint is up now: https://t.co/vTsqH4Hyo4. Biggest changes: we compare polygenic risk sc…
RT @bvilhjal: Yet another interesting paper from @genetisaur https://t.co/D75jmUv24t
RT @genetisaur: Update! A revised version of our preprint is up now: https://t.co/vTsqH4Hyo4. Biggest changes: we compare polygenic risk sc…
RT @genetisaur: Update! A revised version of our preprint is up now: https://t.co/vTsqH4Hyo4. Biggest changes: we compare polygenic risk sc…
RT @genetisaur: Update! A revised version of our preprint is up now: https://t.co/vTsqH4Hyo4. Biggest changes: we compare polygenic risk sc…
RT @genetisaur: Update! A revised version of our preprint is up now: https://t.co/vTsqH4Hyo4. Biggest changes: we compare polygenic risk sc…
RT @genetisaur: Update! A revised version of our preprint is up now: https://t.co/vTsqH4Hyo4. Biggest changes: we compare polygenic risk sc…
(11) Beyond these conceptual issues, there are a lot of reasons to think that polygenic scores don't translate well between populations. @genetisaur's work has been a major touchpoint for a lot of us here, for example figures 2 and 3 here: https://t.co/ewR
RT @GWAS_lit: Hidden 'risk' in polygenic scores: clinical use today could exacerbate health disparities https://t.co/mwRxs1P3Gx https://t.c…
RT @genetisaur: Update! A revised version of our preprint is up now: https://t.co/vTsqH4Hyo4. Biggest changes: we compare polygenic risk sc…
RT @GWAS_lit: Hidden 'risk' in polygenic scores: clinical use today could exacerbate health disparities https://t.co/mwRxs1P3Gx https://t.c…
RT @GWAS_lit: Hidden 'risk' in polygenic scores: clinical use today could exacerbate health disparities https://t.co/mwRxs1P3Gx https://t.c…
RT @GWAS_lit: Hidden 'risk' in polygenic scores: clinical use today could exacerbate health disparities https://t.co/mwRxs1P3Gx https://t.c…
RT @GWAS_lit: Hidden 'risk' in polygenic scores: clinical use today could exacerbate health disparities https://t.co/mwRxs1P3Gx https://t.c…
RT @genetisaur: Update! A revised version of our preprint is up now: https://t.co/vTsqH4Hyo4. Biggest changes: we compare polygenic risk sc…
Super important (and clearly written) paper on the significant issues around development and application of polygenic scores across populations
RT @genetisaur: Update! A revised version of our preprint is up now: https://t.co/vTsqH4Hyo4. Biggest changes: we compare polygenic risk sc…
@EllieRaffan
RT @genetisaur: Update! A revised version of our preprint is up now: https://t.co/vTsqH4Hyo4. Biggest changes: we compare polygenic risk sc…
RT @genetisaur: Update! A revised version of our preprint is up now: https://t.co/vTsqH4Hyo4. Biggest changes: we compare polygenic risk sc…
RT @GWAS_lit: Hidden 'risk' in polygenic scores: clinical use today could exacerbate health disparities https://t.co/mwRxs1P3Gx https://t.c…
RT @genetisaur: Update! A revised version of our preprint is up now: https://t.co/vTsqH4Hyo4. Biggest changes: we compare polygenic risk sc…
One step further to improve personalized medicine via #genetics #sequencing and improve disparity there.
RT @genetisaur: Update! A revised version of our preprint is up now: https://t.co/vTsqH4Hyo4. Biggest changes: we compare polygenic risk sc…
RT @genetisaur: Update! A revised version of our preprint is up now: https://t.co/vTsqH4Hyo4. Biggest changes: we compare polygenic risk sc…
And it’s not necessarily getting better! https://t.co/ETgNr8LVHP
There’s a desperate need for more genetics work in non-white populations.
RT @genetisaur: Update! A revised version of our preprint is up now: https://t.co/vTsqH4Hyo4. Biggest changes: we compare polygenic risk sc…
RT @genetisaur: Update! A revised version of our preprint is up now: https://t.co/vTsqH4Hyo4. Biggest changes: we compare polygenic risk sc…
RT @genetisaur: Update! A revised version of our preprint is up now: https://t.co/vTsqH4Hyo4. Biggest changes: we compare polygenic risk sc…
RT @bvilhjal: Yet another interesting paper from @genetisaur https://t.co/D75jmUv24t
RT @genetisaur: Update! A revised version of our preprint is up now: https://t.co/vTsqH4Hyo4. Biggest changes: we compare polygenic risk sc…
RT @genetisaur: Update! A revised version of our preprint is up now: https://t.co/vTsqH4Hyo4. Biggest changes: we compare polygenic risk sc…
RT @GWAS_lit: Hidden 'risk' in polygenic scores: clinical use today could exacerbate health disparities https://t.co/mwRxs1P3Gx https://t.c…