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Cold Spring Harbor Laboratory Press

Evidence of recombination in coronaviruses implicating pangolin origins of nCoV-2019

Overview of attention for article published in bioRxiv, February 2020
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Title
Evidence of recombination in coronaviruses implicating pangolin origins of nCoV-2019
Published in
bioRxiv, February 2020
DOI 10.1101/2020.02.07.939207
Pubmed ID
Authors

Matthew C. Wong, Sara J. Javornik Cregeen, Nadim J. Ajami, Joseph F. Petrosino

Abstract

A novel coronavirus (nCoV-2019) was the cause of an outbreak of respiratory illness detected in Wuhan, Hubei Province, China in December of 2019. Genomic analyses of nCoV-2019 determined a 96% resemblance with a coronavirus isolated from a bat in 2013 (RaTG13); however, the receptor binding motif (RBM) of these two genomes share low sequence similarity. This divergence suggests a possible alternative source for the RBM coding sequence in nCoV-2019. We identified high sequence similarity in the RBM between nCoV-2019 and a coronavirus genome reconstructed from a viral metagenomic dataset from pangolins possibly indicating a more complex origin for nCoV-2019.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 364 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 364 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 59 16%
Researcher 53 15%
Student > Bachelor 44 12%
Student > Ph. D. Student 32 9%
Other 21 6%
Other 59 16%
Unknown 96 26%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 80 22%
Medicine and Dentistry 48 13%
Agricultural and Biological Sciences 29 8%
Immunology and Microbiology 16 4%
Veterinary Science and Veterinary Medicine 12 3%
Other 70 19%
Unknown 109 30%