@SashaGusevPosts The effect of rare variants is known to be significantly large for certain phenotypes
@pp0196 Yeah, this paper (and a few others recently) is starting to quantify the nulls from WGS. But the Wainschtein et al. h2 analysis was done four years ago [https://t.co/3bjJBlFxfZ] and it's odd there hasn't been a follow-up with the much better data n
@gabriel_mathy @IronEconomist @rfitz77 Theoretical analyses suggest rare SNPs will close gap with, eg, twin study h2 estimates. But need big samples of *whole genome* (not SNP array) genotypes for working predictors of this type. SE of existing predictor
RT @0xdoug: @SashaGusevPosts @Willyintheworld @ruth_hook_ You're citing a 2015 GCTA paper, finding 56% heridatibility for height. Yet a muc…
@SashaGusevPosts @Willyintheworld @ruth_hook_ You're citing a 2015 GCTA paper, finding 56% heridatibility for height. Yet a much larger 2019 study, explicitly found 79% heridatibility by explicitly tracking MAF. That's pretty solid evidence that GCTA is
@tadesouaiaia @dodderidge @capitalismandf1 @ImmuneHack Rare variants do indeed make up a large portion of heritable variance
@OscardelaCroixS Además, también hay ejemplos de rasgos (como la altura) cuya heredabilidad en estudios genómicos y estudios de gemelos no coincide porque los primeros se basan generalmente en alelos comunes. Cuando incluyes alelos raros, las estimaciones
WGS data recovers additional heritability due to rare variants for height (h2=0.68). https://t.co/Xmeg8b683D However, I vaguely remember another pre-print from same authors a while ago, with a higher estimate (h2=0.79) https://t.co/BcHaWQSm7Q. Wondering wh
@doctorveera @ShaiCarmi @michelnivard @AlexTISYoung Also I think consistent with the GCTA estimates with an additional 20% or so coming from untagged rate variants. https://t.co/qOgrcQ5orj
@SecretBaboon According to the latest architectural paper pertaining to human height (2019), all of the pedigree heritability (79%) has now been fully accounted for. https://t.co/XfNjoC1iRZ https://t.co/jONBPW8l74
@NiklasLangstrom Notera t.ex. Peter Visschers senaste pek som avser undersöka heritabiliteten för kroppslängd och BMI med helgenomsekvensering. Det visar sig att mycket av "missing heritability"-problemet återfinns bland mer sällsynta genvarianter. https:/
@KirkegaardEmil Maybe, maybe not. Either way this makes things more difficult.
RT @WiringTheBrain: Rare variants explain "missing heritability" https://t.co/XIWIviKo6S https://t.co/mi1W2EQj52
RT @WiringTheBrain: Rare variants explain "missing heritability" https://t.co/XIWIviKo6S https://t.co/mi1W2EQj52
RT @WiringTheBrain: Rare variants explain "missing heritability" https://t.co/XIWIviKo6S https://t.co/mi1W2EQj52
RT @WiringTheBrain: Rare variants explain "missing heritability" https://t.co/XIWIviKo6S https://t.co/mi1W2EQj52
RT @WiringTheBrain: Rare variants explain "missing heritability" https://t.co/XIWIviKo6S https://t.co/mi1W2EQj52
Recovery of trait heritability from whole genome sequence data | bioRxiv https://t.co/a41EfVIe55
RT @WiringTheBrain: Rare variants explain "missing heritability" https://t.co/XIWIviKo6S https://t.co/mi1W2EQj52
RT @WiringTheBrain: Rare variants explain "missing heritability" https://t.co/XIWIviKo6S https://t.co/mi1W2EQj52
More complex systems have more ways to fail. The degradation of complexity often seems idiosyncratic especially at first. (Earlier versions of these complex trait observations can be found under mutation load, and then genetic load.)
RT @WiringTheBrain: Rare variants explain "missing heritability" https://t.co/XIWIviKo6S https://t.co/mi1W2EQj52
RT @WiringTheBrain: Rare variants explain "missing heritability" https://t.co/XIWIviKo6S https://t.co/mi1W2EQj52
RT @WiringTheBrain: Rare variants explain "missing heritability" https://t.co/XIWIviKo6S https://t.co/mi1W2EQj52
RT @WiringTheBrain: Rare variants explain "missing heritability" https://t.co/XIWIviKo6S https://t.co/mi1W2EQj52
RT @WiringTheBrain: Rare variants explain "missing heritability" https://t.co/XIWIviKo6S https://t.co/mi1W2EQj52
RT @WiringTheBrain: Rare variants explain "missing heritability" https://t.co/XIWIviKo6S https://t.co/mi1W2EQj52
Que resulta que si usas un método que por necesidad infravalora la heredabilidad al mirar solo variantes comunes luego cuando miras las variantes raras la supuesta 'missing heritability' comparando con estudios de gemelos y similares se esfuma bastante ht
RT @Rosalind_Arden_: new work led by @w_pierrick implies "rare variants, in particular those in regions of low LD, is (sic) a major source…
RT @WiringTheBrain: Rare variants explain "missing heritability" https://t.co/XIWIviKo6S https://t.co/mi1W2EQj52
RT @WiringTheBrain: Rare variants explain "missing heritability" https://t.co/XIWIviKo6S https://t.co/mi1W2EQj52
RT @WiringTheBrain: Rare variants explain "missing heritability" https://t.co/XIWIviKo6S https://t.co/mi1W2EQj52
new work led by @w_pierrick implies "rare variants, in particular those in regions of low LD, is (sic) a major source of the still missing heritability of complex traits" pre-print https://t.co/POiaABSAtN
RT @WiringTheBrain: Rare variants explain "missing heritability" https://t.co/XIWIviKo6S https://t.co/mi1W2EQj52
RT @WiringTheBrain: Rare variants explain "missing heritability" https://t.co/XIWIviKo6S https://t.co/mi1W2EQj52
RT @WiringTheBrain: Rare variants explain "missing heritability" https://t.co/XIWIviKo6S https://t.co/mi1W2EQj52
RT @WiringTheBrain: Rare variants explain "missing heritability" https://t.co/XIWIviKo6S https://t.co/mi1W2EQj52
RT @WiringTheBrain: Rare variants explain "missing heritability" https://t.co/XIWIviKo6S https://t.co/mi1W2EQj52
RT @WiringTheBrain: Rare variants explain "missing heritability" https://t.co/XIWIviKo6S https://t.co/mi1W2EQj52
RT @WiringTheBrain: Rare variants explain "missing heritability" https://t.co/XIWIviKo6S https://t.co/mi1W2EQj52
"Rare variants, in particular those in regions of low LD, [are] a major source of the still missing heritability of complex traits and disease." https://t.co/DYJF9x5t3v
Rare variants explain "missing heritability" https://t.co/XIWIviKo6S https://t.co/mi1W2EQj52
RT @GWAS_lit: Recovery of trait heritability from whole genome sequence data https://t.co/TIAVYsV4T8 https://t.co/NQlrEmvVCN
RT @GWAS_lit: Recovery of trait heritability from whole genome sequence data https://t.co/TIAVYsV4T8 https://t.co/NQlrEmvVCN
RT @GWAS_lit: Recovery of trait heritability from whole genome sequence data https://t.co/TIAVYsV4T8 https://t.co/NQlrEmvVCN
RT @GWAS_lit: Recovery of trait heritability from whole genome sequence data https://t.co/TIAVYsV4T8 https://t.co/NQlrEmvVCN
RT @GWAS_lit: Recovery of trait heritability from whole genome sequence data https://t.co/TIAVYsV4T8 https://t.co/NQlrEmvVCN
RT @GWAS_lit: Recovery of trait heritability from whole genome sequence data https://t.co/TIAVYsV4T8 https://t.co/NQlrEmvVCN
RT @GWAS_lit: Recovery of trait heritability from whole genome sequence data https://t.co/TIAVYsV4T8 https://t.co/NQlrEmvVCN
RT @GWAS_lit: Recovery of trait heritability from whole genome sequence data https://t.co/TIAVYsV4T8 https://t.co/NQlrEmvVCN
RT @GWAS_lit: Recovery of trait heritability from whole genome sequence data https://t.co/TIAVYsV4T8 https://t.co/NQlrEmvVCN
RT @GWAS_lit: Recovery of trait heritability from whole genome sequence data https://t.co/TIAVYsV4T8 https://t.co/NQlrEmvVCN
Recovery of trait heritability from whole genome sequence data https://t.co/TIAVYsV4T8 https://t.co/NQlrEmvVCN
@gwern @bowserbot2 ah two were accidentally concatenated cause they were separated by a + with no spaces https://t.co/wfZl8KI2Py https://t.co/bImySEqL2t
@jpirruccello @dr_appie @PCTGenomics Hi James. In an ‘ideal’ world it would look like the simulations in the supp, no difference between unrelated and relatives. Pierrick has been looking into WGS with TOPMed: https://t.co/Lij9YixD1g
@whsource Actual full genome data also estimated heritability to be ~40%. https://t.co/31bgkmxpJt . This agrees with the Elks et al family based heritability estimate, see fig 4 in Elks.
@jflier @StephenORahilly Not Steve but you may find these helpful. ~6% of BMI variance had been correlated with 941 loci as of 2018 (n = 700k GWAS). Has probably been superseded by now. https://t.co/xhmQbmHjBH https://t.co/BWbR4rlN81 https://t.co/VBf109s
@saraannhart If you are wondering about any quantitative trait, trait heritability can be fully recovered using WGS data! https://t.co/kSDkFXbkvz. Basically rare variants are important and there are other cool papers by Ryan Hernandez’s group at McGill you
‘Landmark’ study resolves a major mystery of how genes govern human height https://t.co/m8aocIVJU0 Recovery of trait heritability from whole-genome sequence data https://t.co/05c1bYYeYB
@primalpoly To be clear, I'm quoting this SNP-heritability from the preprint cited by your link: https://t.co/bmfNCzRCdo
@venkmurthy @rasmansa Fully agree about the rosy picture and the G*E bit (but it helps to discuss h2 and caveats, etc) I bet the orig. tweet had the GWAS for behaviour, income, etc, in mind. But we cant leave people unprepared given this is already here h
@ynakahashi1003 ご関心、どうも有難うございます。2型糖尿病ではまだMissing heritabilityが著しく課題となっているようですが・・ Phenotypeによっては差も縮まっていると教えて頂きました⬇️ https://t.co/4tqAJZDvsl
一応、全ゲノムシーケンスデータを使うと身長については家系研究とほぼ等しい値が得られていて、BMIもあと少しのところまで来ているようです:https://t.co/YlM76yu4L8 ただ、遺伝率推定業界はまだいろいろ議論があるので決定打かはわかりません。
@CIoakim @gcochran99 @NoahCracky @jayjoseph22 The heritability gap has been resolved. See Visscher's work from last year: https://t.co/1rgBqDBJmi As Greg and anyone with any quant genetics expertise suggested, the "missing" heritability is in rare varian
RT @whsource: @Willy_Chertman I don't know what qualifies as "bad". GWAS for BMI is at n = ~700k and is explaining ~6% of BMI variance las…
@Willy_Chertman I don't know what qualifies as "bad". GWAS for BMI is at n = ~700k and is explaining ~6% of BMI variance last time I checked. That's out of a possible ~75% suggested by twin studies. This study may be relevant though. https://t.co/VBf109
"The missing heritability of complex traits and disease is accounted for by rare variants." https://t.co/IAwgqLMPcl
@westwoodsam1 42+43/ It's cool to think that it took less than a decade to hit the numbers for schizophrenia and do cool research on height using whole genome sequencing in a much smaller number of people [https://t.co/MG7yKt5WoF] than anticipated in this
Recovery of trait heritability from whole genome sequence data: https://t.co/B6PFXv1iHV #genomics #privacy
RT @mrtnj: Visscher: estimating genomic heritability with genome sequence data. "At face value, this is consistent with recovering the full…
Visscher: estimating genomic heritability with genome sequence data. "At face value, this is consistent with recovering the full pedigree heritability." #GenSoc100 https://t.co/C330kLjZFq
@sillyolyou @ChrisSylvain @CaulfieldTim @pp0196 Actually, it's blatantly true. See the latest research from Peter Visscher, one of the leaders of the GWAS field. https://t.co/VBf109sUKH
Hey @biorxivpreprint, this paper most certainly isn't "published" in Paediatric Endocrinology! https://t.co/yxzrE6QFsE (@cshperspectives)
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
Recovery of trait heritability from whole genome sequence data | bioRxiv https://t.co/bAejqnX0Wy
RT @shi_huang5: "Low-MAF variants..... consistent with negative selection thereon." The finding of rare variants under negative selection i…
So tell me more about how sound OOA is? @WiringTheBrain @FilthyMonkeyMen @Steve_Sailer @clairlemon
"Low-MAF variants..... consistent with negative selection thereon." The finding of rare variants under negative selection is consistent with the reality of maximum saturation in genetic diversity or the MGD theory, invalidating the neutral theory and OOA.
@shi_huang5 This paper furthers your parallel mutation argument, as the fact that unshared/rare and low-LD alleles support the same phylogenic function means they must have emerged in parallel at different loci https://t.co/wv7bQHLxGN
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
Adding rare variants to SNP-based heritability goes up to 40% https://t.co/LX4D8kAjzX
RT @Dr_C_Llewellyn: @BrownAdey @MaritaHennessy @FionaQuigs @Jane1Ogden @Farooqi_Lab This preprint from Peter Vischer's group is able to exp…
RT @Dr_C_Llewellyn: @BrownAdey @MaritaHennessy @FionaQuigs @Jane1Ogden @Farooqi_Lab This preprint from Peter Vischer's group is able to exp…
@BrownAdey @MaritaHennessy @FionaQuigs @Jane1Ogden @Farooqi_Lab This preprint from Peter Vischer's group is able to explain 40% of variation in BMI using 47 million measured common genetic variants (SNPs) - & 51% from v rare variants. Needs to be publi
@hovatta @negenfi Heritabiliteetti on kovaa vauhtia kääntymässä yksilötasolle polygeenisten riskimuuttujien kautta, kuten tiedät. Uusimmilla menetelmillä DNA-pohjainen periytyvyys myös lähestyy kaksostutkimusten estimaatteja: https://t.co/uqRxfTnAbR
RT @Dongnhu_Truong: Recovery of trait heritability from whole genome sequence data https://t.co/kSDkFXsVn7
Recovery of trait heritability from whole genome sequence data https://t.co/kSDkFXsVn7
RT @dr_appie: Enjoyed Peter Visschers presentation on the @PGCgenetics call on recovering the heritability as estimated in twin studies for…
RT @dr_appie: Enjoyed Peter Visschers presentation on the @PGCgenetics call on recovering the heritability as estimated in twin studies for…
RT @dr_appie: Enjoyed Peter Visschers presentation on the @PGCgenetics call on recovering the heritability as estimated in twin studies for…
RT @dr_appie: Enjoyed Peter Visschers presentation on the @PGCgenetics call on recovering the heritability as estimated in twin studies for…
RT @dr_appie: Enjoyed Peter Visschers presentation on the @PGCgenetics call on recovering the heritability as estimated in twin studies for…
RT @dr_appie: Enjoyed Peter Visschers presentation on the @PGCgenetics call on recovering the heritability as estimated in twin studies for…
RT @dr_appie: Enjoyed Peter Visschers presentation on the @PGCgenetics call on recovering the heritability as estimated in twin studies for…
RT @dr_appie: Enjoyed Peter Visschers presentation on the @PGCgenetics call on recovering the heritability as estimated in twin studies for…
RT @dr_appie: Enjoyed Peter Visschers presentation on the @PGCgenetics call on recovering the heritability as estimated in twin studies for…
RT @dr_appie: Enjoyed Peter Visschers presentation on the @PGCgenetics call on recovering the heritability as estimated in twin studies for…