RT @dr_appie: Enjoyed Peter Visschers presentation on the @PGCgenetics call on recovering the heritability as estimated in twin studies for…
RT @dr_appie: Enjoyed Peter Visschers presentation on the @PGCgenetics call on recovering the heritability as estimated in twin studies for…
RT @dr_appie: Enjoyed Peter Visschers presentation on the @PGCgenetics call on recovering the heritability as estimated in twin studies for…
RT @dr_appie: Enjoyed Peter Visschers presentation on the @PGCgenetics call on recovering the heritability as estimated in twin studies for…
RT @dr_appie: Enjoyed Peter Visschers presentation on the @PGCgenetics call on recovering the heritability as estimated in twin studies for…
RT @dr_appie: Enjoyed Peter Visschers presentation on the @PGCgenetics call on recovering the heritability as estimated in twin studies for…
RT @dr_appie: Enjoyed Peter Visschers presentation on the @PGCgenetics call on recovering the heritability as estimated in twin studies for…
RT @dr_appie: Enjoyed Peter Visschers presentation on the @PGCgenetics call on recovering the heritability as estimated in twin studies for…
Enjoyed Peter Visschers presentation on the @PGCgenetics call on recovering the heritability as estimated in twin studies for height and BMI using whole genome sequencing data. Very exciting results. Check out their preprint here: https://t.co/H0qTL0DRnQ h
@markmccarthyoxf Curious - does this statement ('further analysis indicate that heritabilty of most complex traits is attributable to modest-effect common regulatory variants') still apply (at least to BMI and height) given the recent paper by Peter Vissch
RT @SoyBaseDatabase: Recovery of trait heritability from whole genome sequence data #GWAS "Our results imply that the still missing herita…
RT @SoyBaseDatabase: Recovery of trait heritability from whole genome sequence data #GWAS "Our results imply that the still missing herita…
RT @SoyBaseDatabase: Recovery of trait heritability from whole genome sequence data #GWAS "Our results imply that the still missing herita…
RT @SoyBaseDatabase: Recovery of trait heritability from whole genome sequence data #GWAS "Our results imply that the still missing herita…
Recovery of trait heritability from whole genome sequence data #GWAS "Our results imply that the still missing heritability of complex traits and disease is accounted for by rare variants.." https://t.co/mBQcw8fJIj
RT @fellgernon: Now Bogdan Pasaniuc @bpasaniuc on comparing SNP heritability against heritability: we need to keep in mind the SNPs Loh et…
Now Bogdan Pasaniuc @bpasaniuc on comparing SNP heritability against heritability: we need to keep in mind the SNPs Loh et al Nat Genet 2015 & others like Wainschetein https://t.co/438pomQkce have recovered heritability https://t.co/Pkrlrs2lL9 https:
Another preprint argues for a substantial role of RVs for height and BMI (https://t.co/yxzrE6QFsE).
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
Recovering heritability in a 20k genome study. Finds rare gene variants are responsible for various physical traits and diseases. It estimated a heritability of 79% for height and 40% for Body Mass Index (BMI). @PCTGenomics @biorxiv_genetic https://t.co/4n
RT @zakkohane: Why—on average—are children average height of parents? Common genetic variants don't explain enough of it. Brilliant work…
#Genetic study homes in on height’s heritability mystery Analysis of 20,000 genomes reveals that rare gene variants can help to explain how the trait is inherited. https://t.co/SQan3Ix2sS https://t.co/wjAr15JFQg #Genomics #Research HT @NaturePodcast https:
Recovery of trait heritability from whole genome sequence data https://t.co/ODcz3iPzXA
RT @zakkohane: Why—on average—are children average height of parents? Common genetic variants don't explain enough of it. Brilliant work…
RT @rplenge: “Our results imply that the still missing heritability of complex traits and disease is accounted for by rare variants, in par…
RT @HeWaHippo: Body height has always been the "pioneer trait" for the genetics of complex traits. Here, a preprint of the genetics of body…
Body height has always been the "pioneer trait" for the genetics of complex traits. Here, a preprint of the genetics of body height using whole genome sequence data https://t.co/vQQKbofP8x
RT @zakkohane: Why—on average—are children average height of parents? Common genetic variants don't explain enough of it. Brilliant work…
RT @zakkohane: Why—on average—are children average height of parents? Common genetic variants don't explain enough of it. Brilliant work…
#precisionWellness Why are children growing to about the #height of their #parents on average? Comprehensive trait #heritability study from whole genome sequence data #GWAS https://t.co/eePMaJcN8J #PMI
RT @rplenge: “Our results imply that the still missing heritability of complex traits and disease is accounted for by rare variants, in par…
Really quite excited by this seminal paper 'Recovery of trait heritability from whole genome sequence data' https://t.co/XyPGeEeNpB - nicely supports our work investigating rare variants in Type 2 Diabetes risk
RT @zakkohane: Reminder: BMI much much less influenced by genetics than height. From leading genetics group @PCTGenomics https://t.co/UQrs…
RT @rplenge: “Our results imply that the still missing heritability of complex traits and disease is accounted for by rare variants, in par…
RT @zakkohane: Reminder: BMI much much less influenced by genetics than height. From leading genetics group @PCTGenomics https://t.co/UQrs…
Reminder: BMI much much less influenced by genetics than height. From leading genetics group @PCTGenomics https://t.co/UQrsypl0YC reinforcing message to parents and pediatricians where obesity problem lies @commonhealth @MuinJKhoury @SueDHellmann @NAChri
RT @zakkohane: Why—on average—are children average height of parents? Common genetic variants don't explain enough of it. Brilliant work…
RT @zakkohane: Why—on average—are children average height of parents? Common genetic variants don't explain enough of it. Brilliant work…
Why—on average—are children average height of parents? Common genetic variants don't explain enough of it. Brilliant work ; Visscher et al @PCTGenomics https://t.co/XLI0WfOqPD RARE variants picked up on whole genome scan provide that large missing herit
RT @rplenge: “Our results imply that the still missing heritability of complex traits and disease is accounted for by rare variants, in par…
RT @Bio_stations: これはすごい! 2万人以上の全ゲノムを解読し、ゲノムと身長との関係を網羅的に洗い出した。 結果、ゲノムによって身長は79%程度説明できるらしい。 もちろん身長に限らず、未知SNPも多数発見している! Recovery of trait…
RT @Bio_stations: これはすごい! 2万人以上の全ゲノムを解読し、ゲノムと身長との関係を網羅的に洗い出した。 結果、ゲノムによって身長は79%程度説明できるらしい。 もちろん身長に限らず、未知SNPも多数発見している! Recovery of trait…
RT @rplenge: “Our results imply that the still missing heritability of complex traits and disease is accounted for by rare variants, in par…
RT @rplenge: “Our results imply that the still missing heritability of complex traits and disease is accounted for by rare variants, in par…
RT @rplenge: “Our results imply that the still missing heritability of complex traits and disease is accounted for by rare variants, in par…
RT @Bio_stations: これはすごい! 2万人以上の全ゲノムを解読し、ゲノムと身長との関係を網羅的に洗い出した。 結果、ゲノムによって身長は79%程度説明できるらしい。 もちろん身長に限らず、未知SNPも多数発見している! Recovery of trait…
RT @rplenge: “Our results imply that the still missing heritability of complex traits and disease is accounted for by rare variants, in par…
RT @P_Amouyel: The missing heritability hidden behind gene rare variants for height and BMI. Should we go to systematic whole genome sequen…
RT @rplenge: “Our results imply that the still missing heritability of complex traits and disease is accounted for by rare variants, in par…
RT @rplenge: “Our results imply that the still missing heritability of complex traits and disease is accounted for by rare variants, in par…
RT @Bio_stations: これはすごい! 2万人以上の全ゲノムを解読し、ゲノムと身長との関係を網羅的に洗い出した。 結果、ゲノムによって身長は79%程度説明できるらしい。 もちろん身長に限らず、未知SNPも多数発見している! Recovery of trait…
The missing heritability hidden behind gene rare variants for height and BMI. Should we go to systematic whole genome sequencing to solve the heritability of complex diseases? https://t.co/Nh3keSUEGl https://t.co/QrKLEnUyde
RT @rplenge: “Our results imply that the still missing heritability of complex traits and disease is accounted for by rare variants, in par…
The case for WGS.
RT @rplenge: “Our results imply that the still missing heritability of complex traits and disease is accounted for by rare variants, in par…
Wow!
Genetic study homes in on height’s heritability mystery | Nature https://t.co/laMwZ0b8WK https://t.co/4Zu4h04gee #genetics #height https://t.co/ujmbVXVDuD
“Our results imply that the still missing heritability of complex traits and disease is accounted for by rare variants, in particular those in regions of low LD.” https://t.co/KOlLJahavy
Recovery of trait heritability from whole genome sequence data https://t.co/kwCpjR3vMG
Recovery of trait heritability from whole genome sequence data https://t.co/Yv65F33GDn
RT @pnatarajanmd: In TOPMed WGS analysis of N~20K, ~50% of height & BMI heritability explained by rare/low-frequency variants (MAF 0.0001-0…
A tale of missing heritability, BMI, height in era of Whole #genome sequencing, #GWAS for assessing complex traits What’s the buzz? #BioInformatics #Statistics #epitwitter #genomics Recovery of trait heritability from whole genome sequence data | bioRxiv
RT @Bio_stations: これはすごい! 2万人以上の全ゲノムを解読し、ゲノムと身長との関係を網羅的に洗い出した。 結果、ゲノムによって身長は79%程度説明できるらしい。 もちろん身長に限らず、未知SNPも多数発見している! Recovery of trait…
RT @Bio_stations: これはすごい! 2万人以上の全ゲノムを解読し、ゲノムと身長との関係を網羅的に洗い出した。 結果、ゲノムによって身長は79%程度説明できるらしい。 もちろん身長に限らず、未知SNPも多数発見している! Recovery of trait…
In TOPMed WGS analysis of N~20K, ~50% of height & BMI heritability explained by rare/low-frequency variants (MAF 0.0001-0.1) https://t.co/B9sCgPwGjy @biorxiv_genomic (covered in https://t.co/27acRsm3Ak @NatureNews)
RT @Bio_stations: これはすごい! 2万人以上の全ゲノムを解読し、ゲノムと身長との関係を網羅的に洗い出した。 結果、ゲノムによって身長は79%程度説明できるらしい。 もちろん身長に限らず、未知SNPも多数発見している! Recovery of trait…
しゅごい
RT @Bio_stations: これはすごい! 2万人以上の全ゲノムを解読し、ゲノムと身長との関係を網羅的に洗い出した。 結果、ゲノムによって身長は79%程度説明できるらしい。 もちろん身長に限らず、未知SNPも多数発見している! Recovery of trait…
これはすごい! 2万人以上の全ゲノムを解読し、ゲノムと身長との関係を網羅的に洗い出した。 結果、ゲノムによって身長は79%程度説明できるらしい。 もちろん身長に限らず、未知SNPも多数発見している! Recovery of trait heritability from whole genome sequence data https://t.co/AfNJHuqu0c
#science #heightheritability About 80% of variation in height is down to genetics. But since the human genome was sequenced nearly two decades ago, researchers have struggled to fully identify the genetic factors responsible. https://t.co/CCRZH1jyAr https:
RT @huangyifeicmb: @jo_schacherer @leonidkruglyak This is very exciting. Thanks. With another study of human quantitative traits https://t.…
RT @huangyifeicmb: @jo_schacherer @leonidkruglyak This is very exciting. Thanks. With another study of human quantitative traits https://t.…
@jo_schacherer @leonidkruglyak This is very exciting. Thanks. With another study of human quantitative traits https://t.co/UEEir6toR9, are we approaching a conclusion that rare variants are fundamentally important in quantitative traits?
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @GWAS_lit: Recovery of trait heritability from whole genome sequence data https://t.co/8yYNUswOfp https://t.co/COieU36YXM
@JLipsanen Vrt. tämä: https://t.co/uqRxfTnAbR
This is a real watershed. We're now getting the same heritability estimates for height (~80%) using DNA as do with twin/adoption designs. How long until we see the same thing done for complex *behavioural* traits like educational attainment?! Exciting time
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
WGS recovers pedigree heritability for height & BMI. @rdhernand - how do results look if you mimic a WES strategy? https://t.co/Tt8S1fpQxr
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
Closing that gap: Recovery of trait heritability from whole genome sequence data https://t.co/WkETEgWalE (20)
Recovery of trait heritability from whole genome sequence data https://t.co/OEiEKLNMtm
Are we now resolving missing heritability? More genomes needed Recovery of trait heritability from whole genome sequence data | bioRxiv https://t.co/OWFNDpK26A
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @jyang1981: Recovery of trait heritability from whole genome sequence data https://t.co/DLpCSz40j1
RT @primalpoly: tl;dr: you no longer need twin/family studies to estimate heritability of a trait. You can just do it from big samples of p…
RT @RyanLCollins13: Whoa😮 seems like a pretty major finding: "...variants in the MAF range of 0.0001 to 0.1 explained 0.54 and 0.51 of heri…
RT @pitiklinov: Hasta ahora había un desfase entre la heredabilidad que se hallaba en estudios de gemelos y familiares en general y la que…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @RyanLCollins13: Whoa😮 seems like a pretty major finding: "...variants in the MAF range of 0.0001 to 0.1 explained 0.54 and 0.51 of heri…
... We also discuss missing heritability and the publication of https://t.co/U4JZMKbyVc . Also, what's stopping/encouraging the adoption of #NGS in #clinicalpractice ...
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
https://t.co/WOyfL8vGQd Supposedly this is a BIG result in genetics and I'm trying hard to understand why, wish me luck.
For those that doubted : Recovery of trait heritability from whole genome sequence data | bioRxiv https://t.co/UDtgFjryZz
RT @ProfSimonFisher: It took a decade, but "the case of the missing heritability" is solved! Rare variants save the day in this cool whole…
RT @WiringTheBrain: This really impressive work by Wainschtein, Visscher, @jyang1981 et al, shows that is indeed the case: Recovery of trai…