Recovery of trait heritability from whole genome sequence data https://t.co/hFsgcnkzSk The virus-driven degradation of messenger RNA causes "...the still missing heritability of complex traits and disease..." which they claim is accounted for by rare varia
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @SteveStuWill: Why are DNA-based heritability estimates lower than those based on twin studies? A big part of it seems to be that the fo…
RT @WiringTheBrain: This really impressive work by Wainschtein, Visscher, @jyang1981 et al, shows that is indeed the case: Recovery of trai…
RT @SteveStuWill: Why are DNA-based heritability estimates lower than those based on twin studies? A big part of it seems to be that the fo…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
So, it appears we now have 1) the ability to do large-scale genome editing, thousands of edits(https://t.co/b39ry9geI2) 2) the ability to predict almost all variance of quantitative traits by looking at genome(https://t.co/Npdq8lN9RP)
RT @WiringTheBrain: This really impressive work by Wainschtein, Visscher, @jyang1981 et al, shows that is indeed the case: Recovery of trai…
"for low-LD variants with MAF < 0.1, non-synonymous and protein truncating variants on average contributed much more to the heritability estimates than synonymous or non-coding variants, as it might be expected biologically." https://t.co/gaKlFuOSVV
"This method also allowed us to confirm that most of the heritability due to very rare variants (0.0001 < MAF < 0.001) was missing when using imputed data but was revealed by using WGS data." https://t.co/gaKlFuOSVV
"We recover the heritability estimated from pedigree data for both traits and show that the additional variance detected over and above SNP arrays is due to rare variants, in particular rare protein-altering variants in low LD with other genomic variants."
RT @WiringTheBrain: This really impressive work by Wainschtein, Visscher, @jyang1981 et al, shows that is indeed the case: Recovery of trai…
RT @jyang1981: Recovery of trait heritability from whole genome sequence data https://t.co/DLpCSz40j1
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
Great #scicomm thread on the “missing heritability” of traits (due to rare genetic variants not picked up by GWAS) recently investigated by @w_pierrick et al.: https://t.co/gfoFxCqCZ0 Look out for upcoming blogpost by @WiringTheBrain
This really impressive work by Wainschtein, Visscher, @jyang1981 et al, shows that is indeed the case: Recovery of trait heritability from whole genome sequence data https://t.co/T4vswLlWTi https://t.co/47GGCebfjZ
RT @SteveStuWill: Why are DNA-based heritability estimates lower than those based on twin studies? A big part of it seems to be that the fo…
RT @SteveStuWill: Why are DNA-based heritability estimates lower than those based on twin studies? A big part of it seems to be that the fo…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @LHlusko: Fascinating! Our species’ #missingHeritability has been found?!? https://t.co/ov9PU0RKrU
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @SteveStuWill: Why are DNA-based heritability estimates lower than those based on twin studies? A big part of it seems to be that the fo…
RT @SteveStuWill: Why are DNA-based heritability estimates lower than those based on twin studies? A big part of it seems to be that the fo…
RT @SteveStuWill: Why are DNA-based heritability estimates lower than those based on twin studies? A big part of it seems to be that the fo…
RT @SteveStuWill: Why are DNA-based heritability estimates lower than those based on twin studies? A big part of it seems to be that the fo…
RT @SteveStuWill: Why are DNA-based heritability estimates lower than those based on twin studies? A big part of it seems to be that the fo…
RT @SteveStuWill: Why are DNA-based heritability estimates lower than those based on twin studies? A big part of it seems to be that the fo…
RT @SteveStuWill: Why are DNA-based heritability estimates lower than those based on twin studies? A big part of it seems to be that the fo…
RT @SteveStuWill: Why are DNA-based heritability estimates lower than those based on twin studies? A big part of it seems to be that the fo…
Missing h2 seems mainly come from rare variant in low LD region
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @RyanLCollins13: Whoa😮 seems like a pretty major finding: "...variants in the MAF range of 0.0001 to 0.1 explained 0.54 and 0.51 of heri…
RT @PiqueMylnterest: This is kind of a big deal for #genetics coming out of Brisbane! Missing heritability seems to be explained largely b…
RT @primalpoly: tl;dr: you no longer need twin/family studies to estimate heritability of a trait. You can just do it from big samples of p…
RT @pitiklinov: Hasta ahora había un desfase entre la heredabilidad que se hallaba en estudios de gemelos y familiares en general y la que…
This is kind of a big deal for #genetics coming out of Brisbane! Missing heritability seems to be explained largely by rare variants with low LD
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @pitiklinov: Hasta ahora había un desfase entre la heredabilidad que se hallaba en estudios de gemelos y familiares en general y la que…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @jyang1981: Recovery of trait heritability from whole genome sequence data https://t.co/DLpCSz40j1
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @whsource: Yasss. So excited about the rapid progress in human genetics research. This (preprint) study suggests that rare variants ma…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @jyang1981: Recovery of trait heritability from whole genome sequence data https://t.co/DLpCSz40j1
RT @akousathanas: The culmination of 10 years of GWAS research! Estimated heritability of height =0.79 with whole genome sequence data. "Mi…
Heredabilitat en estudis familiars i del genoma complet. Trobant l'heredabilitat perduda,? https://t.co/rxLKkelD4D
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @pitiklinov: Hasta ahora había un desfase entre la heredabilidad que se hallaba en estudios de gemelos y familiares en general y la que…
RT @pitiklinov: Hasta ahora había un desfase entre la heredabilidad que se hallaba en estudios de gemelos y familiares en general y la que…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @pitiklinov: Hasta ahora había un desfase entre la heredabilidad que se hallaba en estudios de gemelos y familiares en general y la que…
Hasta ahora había un desfase entre la heredabilidad que se hallaba en estudios de gemelos y familiares en general y la que aparece en estudios de genoma completo. Aquí dicen que la explicación para esa diferencia está en las variantes genéticas raras https
RT @jsantoyo: Recovery of trait heritability from whole genome sequence data. https://t.co/rlTQMTAizI
RT @mcintosh2001: Recovery of trait heritability from whole genome sequence data https://t.co/8sORRgXJOH
Missing heritability of complex traits and disease is accounted for by rare variants, in particular those in regions of low LD https://t.co/Mo1wDN5vdX
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @whsource: Yasss. So excited about the rapid progress in human genetics research. This (preprint) study suggests that rare variants ma…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @jyang1981: Recovery of trait heritability from whole genome sequence data https://t.co/DLpCSz40j1
RT @carlzimmer: So long, missing heritability? https://t.co/KCS15FMBTI via @evolbrain
RT @cecilejanssens: Missing heritability explained by rare variants? I hope someone will share a plain language explainer. Is this a fitti…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @jyang1981: Recovery of trait heritability from whole genome sequence data https://t.co/DLpCSz40j1
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @SteveStuWill: Why are DNA-based heritability estimates lower than those based on twin studies? A big part of it seems to be that the fo…
Some still missing, some hidden in low LD
RT @ProfSimonFisher: It took a decade, but "the case of the missing heritability" is solved! Rare variants save the day in this cool whole…
RT @whsource: Yasss. So excited about the rapid progress in human genetics research. This (preprint) study suggests that rare variants ma…
RT @jyang1981: Recovery of trait heritability from whole genome sequence data https://t.co/DLpCSz40j1
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @mete_civelek: If the missing heritability can be explained by rare variants, what are we, geneticists, going to debate then? https://t.…
WOW!
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @ProfSimonFisher: It took a decade, but "the case of the missing heritability" is solved! Rare variants save the day in this cool whole…
RT @GWAS_lit: Recovery of trait heritability from whole genome sequence data https://t.co/8yYNUswOfp https://t.co/COieU36YXM
RT @RyanLCollins13: Whoa😮 seems like a pretty major finding: "...variants in the MAF range of 0.0001 to 0.1 explained 0.54 and 0.51 of heri…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @RyanLCollins13: Whoa😮 seems like a pretty major finding: "...variants in the MAF range of 0.0001 to 0.1 explained 0.54 and 0.51 of heri…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @RyanLCollins13: Whoa😮 seems like a pretty major finding: "...variants in the MAF range of 0.0001 to 0.1 explained 0.54 and 0.51 of heri…
RT @evolbrain: Holy shit - missing h2 of height is found in rare variants. This has profound consequences for the genetics of adaptation, s…
RT @RyanLCollins13: Whoa😮 seems like a pretty major finding: "...variants in the MAF range of 0.0001 to 0.1 explained 0.54 and 0.51 of heri…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
Recovery of trait heritability from whole genome sequence data | bioRxiv https://t.co/9mxQCrN7VL, see more https://t.co/UaSzAxtGUD
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…