RT @WiringTheBrain: Recovery of trait heritability from whole genome sequence data https://t.co/T4vswL4luI - really nice papr from @jyang19…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
Recovery of trait heritability from whole genome sequence data | bioRxiv https://t.co/bAejqnX0Wy
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
Reminder to self: read this. Written ~50% of heritability explained by rare variants for height.. So this is the full missing heritability explained?
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @cecilejanssens: Missing heritability explained by rare variants? I hope someone will share a plain language explainer. Is this a fitti…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
My Nancy drew senses are tingling ... 🧐🧐 The “missing” heritability in BMI explained by rare variants
Fascinating! Our species’ #missingHeritability has been found?!?
I second the request for a plain language explainer.
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
Missing heritability mystrey solved?! https://t.co/vZ3DDiBwYR
RT @drderringer: Missing heritability (h2): gene-finding efforts underperform h2 estimates from twin studies. A lurking concern was that tw…
RT @melindacmills: Missing heritability of complex traits (height .79: BMI .40) accounted for by rare variants in low LD regions! https://t…
Interesting to hear from my geneticist friends about these findings.
RT @jyang1981: Recovery of trait heritability from whole genome sequence data https://t.co/DLpCSz40j1
RT @cecilejanssens: Missing heritability explained by rare variants? I hope someone will share a plain language explainer. Is this a fitti…
RT @RyanLCollins13: Whoa😮 seems like a pretty major finding: "...variants in the MAF range of 0.0001 to 0.1 explained 0.54 and 0.51 of heri…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
Recovery of trait heritability from whole genome sequence data https://t.co/hFsgcnCbgU Missing heritability was linked to natural selection for food energy-dependent pheromone-controlled hemoglobin variants in: https://t.co/JH0YdACEwz
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @jyang1981: Recovery of trait heritability from whole genome sequence data https://t.co/DLpCSz40j1
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
Prediction should not be an obsession. If rare variants a so important in disease heritability their use for prediction will be very difficult 🤔
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @RyanLCollins13: Whoa😮 seems like a pretty major finding: "...variants in the MAF range of 0.0001 to 0.1 explained 0.54 and 0.51 of heri…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @philippefroguel: Very important result from Vissher: missing heritability largely explained by rare variants for height and BMI https:/…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @casey6r0wn: RIP missing heritability? https://t.co/TnhH8A6KSw
RT @mete_civelek: If the missing heritability can be explained by rare variants, what are we, geneticists, going to debate then? https://t.…
RT @RyanLCollins13: Whoa😮 seems like a pretty major finding: "...variants in the MAF range of 0.0001 to 0.1 explained 0.54 and 0.51 of heri…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
If the missing heritability can be explained by rare variants, what are we, geneticists, going to debate then?
RT @RyanLCollins13: Whoa😮 seems like a pretty major finding: "...variants in the MAF range of 0.0001 to 0.1 explained 0.54 and 0.51 of heri…
RT @ProfSimonFisher: It took a decade, but "the case of the missing heritability" is solved! Rare variants save the day in this cool whole…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @SteveStuWill: Why are DNA-based heritability estimates lower than those based on twin studies? A big part of it seems to be that the fo…
RT @primalpoly: tl;dr: you no longer need twin/family studies to estimate heritability of a trait. You can just do it from big samples of p…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
It took a decade, but "the case of the missing heritability" is solved! Rare variants save the day in this cool whole genome sequencing study of >21,000 people from Peter Visscher & co. Read the @biorxivpreprint here: https://t.co/rsZ4cJbm7I https:/
RT @jyang1981: Recovery of trait heritability from whole genome sequence data https://t.co/DLpCSz40j1
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
Even their improved methods capturing genetic variance due to rare genetic variants reports a heritability on the low side for BMI, but the point is taken
RT @RyanLCollins13: Whoa😮 seems like a pretty major finding: "...variants in the MAF range of 0.0001 to 0.1 explained 0.54 and 0.51 of heri…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
I'm personally interested in more common things, and rarely have thought about this too much...but seems like rare variants need to be considered by common people like me
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
Recovery of trait heritability from whole genome sequence data https://t.co/AVbwC9ja8H
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @a_husby: End of "missing heritability" and beginning of "omnigenic medicine"? Very interesting perspectives after new paper attributes…
RT @psychgenomics: Now this is interesting: Use of WGS and GREML establishes they can discover near full twin heritability. "Recovery of tr…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @WiringTheBrain: Recovery of trait heritability from whole genome sequence data https://t.co/T4vswL4luI - really nice papr from @jyang19…
RT @primalpoly: tl;dr: you no longer need twin/family studies to estimate heritability of a trait. You can just do it from big samples of p…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
Turns out rare variants might add up to a lot after all.
Recovery of trait heritability from whole genome sequence data https://t.co/GSyfakVWad
Missing heritability explained by rare variants? I hope someone will share a plain language explainer. Is this a fitting exercise or more. Am interested, obviously, in knowing what the value is for polygenic prediction. https://t.co/njgeQN1vQ0
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @philippefroguel: Very important result from Vissher: missing heritability largely explained by rare variants for height and BMI https:/…
Recovery of trait heritability from whole genome sequence data https://t.co/55kbGwoMYb
RT @RyanLCollins13: Whoa😮 seems like a pretty major finding: "...variants in the MAF range of 0.0001 to 0.1 explained 0.54 and 0.51 of heri…
RT @casey6r0wn: RIP missing heritability? https://t.co/TnhH8A6KSw
RT @WiringTheBrain: Recovery of trait heritability from whole genome sequence data https://t.co/T4vswL4luI - really nice papr from @jyang19…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @MattGrossmann: Accounting for rare genetic variants fully closes the gap between lower GWAT estimates of heritability & higher twin stu…
RT @SteveStuWill: Why are DNA-based heritability estimates lower than those based on twin studies? A big part of it seems to be that the fo…
Woah. Could this be the end of "missing heritability"?
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
I can’t help but cheer for the implications re: twin modeling.
Accounting for rare genetic variants fully closes the gap between lower GWAT estimates of heritability & higher twin study estimates, at least for height & BMI https://t.co/RgXGwZjAUM
RT @SteveStuWill: Why are DNA-based heritability estimates lower than those based on twin studies? A big part of it seems to be that the fo…
RT @jyang1981: Recovery of trait heritability from whole genome sequence data https://t.co/DLpCSz40j1
RT @SteveStuWill: Why are DNA-based heritability estimates lower than those based on twin studies? A big part of it seems to be that the fo…
RT @casey6r0wn: RIP missing heritability? https://t.co/TnhH8A6KSw