RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
Recovering missing heritability via whole genome sequencing is a powerful argument for the next step in sequencing for UK Biobank https://t.co/25VG73FdW1
RT @RyanLCollins13: Whoa😮 seems like a pretty major finding: "...variants in the MAF range of 0.0001 to 0.1 explained 0.54 and 0.51 of heri…
RT @mcintosh2001: Recovery of trait heritability from whole genome sequence data https://t.co/8sORRgXJOH
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @melindacmills: Missing heritability of complex traits (height .79: BMI .40) accounted for by rare variants in low LD regions! https://t…
Recovery of trait heritability from whole genome sequence data https://t.co/8sORRgXJOH
Recovery of trait heritability from whole genome sequence data https://t.co/DLpCSz40j1
End of "missing heritability" and beginning of "omnigenic medicine"? Very interesting perspectives after new paper attributes basically all missing heritability to rare genetic variants: https://t.co/nNPELUTvW3
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @RyanLCollins13: Whoa😮 seems like a pretty major finding: "...variants in the MAF range of 0.0001 to 0.1 explained 0.54 and 0.51 of heri…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @robertclab: "Our results imply that the still missing heritability of complex traits and disease is accounted for by rare variants, in…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
Recovery of trait heritability from whole genome sequence data - https://t.co/fSCbkIvxHF
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @casey6r0wn: RIP missing heritability? https://t.co/TnhH8A6KSw
RT @casey6r0wn: RIP missing heritability? https://t.co/TnhH8A6KSw
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @RyanLCollins13: Whoa😮 seems like a pretty major finding: "...variants in the MAF range of 0.0001 to 0.1 explained 0.54 and 0.51 of heri…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @casey6r0wn: RIP missing heritability? https://t.co/TnhH8A6KSw
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @robertclab: "Our results imply that the still missing heritability of complex traits and disease is accounted for by rare variants, in…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @casey6r0wn: RIP missing heritability? https://t.co/TnhH8A6KSw
Recovery of trait heritability from whole genome sequence data https://t.co/YP0wHF2LFt
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
Agreed! Definitely one for my lab's genetics journal club...
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @psychgenomics: Now this is interesting: Use of WGS and GREML establishes they can discover near full twin heritability. "Recovery of tr…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
Very interesting results. Really glad to see the preprint.
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @philippefroguel: Very important result from Vissher: missing heritability largely explained by rare variants for height and BMI https:/…
RT @primalpoly: tl;dr: you no longer need twin/family studies to estimate heritability of a trait. You can just do it from big samples of p…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @philippefroguel: Very important result from Vissher: missing heritability largely explained by rare variants for height and BMI https:/…
RT @melindacmills: Missing heritability of complex traits (height .79: BMI .40) accounted for by rare variants in low LD regions! https://t…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
Missing heritability of complex traits (height .79: BMI .40) accounted for by rare variants in low LD regions! https://t.co/1VBLvJpcMG
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @casey6r0wn: RIP missing heritability? https://t.co/TnhH8A6KSw
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
> results imply the still missing heritability of complex traits and disease is accounted for by rare variants, in particular those in regions of low LD pretty convincing that negative selection acts on height and BMI (but could also be pop expansion)
Will this put the word end to the common/rare variants debate? And will PGRS be able to achieve R2 as high as h2 using rare variants? I am slightly skeptical in both cases but will love to see what is going to happen.
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @Rosalind_Arden_: Recovery of trait heritability from wgs data: "Here we show that pedigree heritability for height and body mass index…
RT @Rosalind_Arden_: Recovery of trait heritability from wgs data: "Here we show that pedigree heritability for height and body mass index…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
Recovery of trait heritability from wgs data: "Here we show that pedigree heritability for height and body mass index (BMI) appears to be fully recovered from whole-genome sequence (WGS) data on 21,620 unrelated individuals of European ancestry" https://t.
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @RyanLCollins13: Whoa😮 seems like a pretty major finding: "...variants in the MAF range of 0.0001 to 0.1 explained 0.54 and 0.51 of heri…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
Huge paper. Still need to sit down and figure out how last week's big news relates: could these results be biased by pop structure? https://t.co/D3qK9EPZIg
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
Wow, rare variant theory back on the map for schizophrenia?
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
Today's thought provoking paper pair: Contrast https://t.co/nPnV8kbgUk with https://t.co/wwPvsQf2up Thoughts are welcome....
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @GWAS_lit: Recovery of trait heritability from whole genome sequence data https://t.co/8yYNUswOfp https://t.co/COieU36YXM
RT @psychgenomics: Now this is interesting: Use of WGS and GREML establishes they can discover near full twin heritability. "Recovery of tr…
Tämähän onkin jo osattu arvata, mutta vihdoin myös mustaa valkealla: Missing heritability of complex traits is accounted for by rare variants. Variants in the MAF range of 0.0001 to 0.1 explained 0.51 (SE 0.11) of heritability for BMI. https://t.co/mg88TaK
RT @philippefroguel: Very important result from Vissher: missing heritability largely explained by rare variants for height and BMI https:/…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @GWAS_lit: Recovery of trait heritability from whole genome sequence data https://t.co/8yYNUswOfp https://t.co/COieU36YXM
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @RyanLCollins13: Whoa😮 seems like a pretty major finding: "...variants in the MAF range of 0.0001 to 0.1 explained 0.54 and 0.51 of heri…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @jsantoyo: Recovery of trait heritability from whole genome sequence data. https://t.co/rlTQMTAizI
Recovery of trait heritability from whole genome sequence data. https://t.co/rlTQMTAizI
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @primalpoly: tl;dr: you no longer need twin/family studies to estimate heritability of a trait. You can just do it from big samples of p…
RT @robertclab: "Our results imply that the still missing heritability of complex traits and disease is accounted for by rare variants, in…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @GWAS_lit: Recovery of trait heritability from whole genome sequence data https://t.co/8yYNUswOfp https://t.co/COieU36YXM
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
"Our results imply that the still missing heritability of complex traits and disease is accounted for by rare variants, in particular those in regions of low LD" https://t.co/nZA5PEgteI by Wainschtein, Visscher & collaborators