La heredabilidad perdida en los estudios tipo GWAS se ha encontrado: estaba escondida en variantes a muy baja frecuencia...
Imagine doing this in @uk_biobank when whole genome sequences are available, other traits will likely follow
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @RyanLCollins13: Whoa😮 seems like a pretty major finding: "...variants in the MAF range of 0.0001 to 0.1 explained 0.54 and 0.51 of heri…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @GWAS_lit: Recovery of trait heritability from whole genome sequence data https://t.co/8yYNUswOfp https://t.co/COieU36YXM
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
mt @SeqComplete : Recovery of trait heritability from whole genome sequence data | bioRxiv https://t.co/9mxQCrN7VL, see more https://t.co/D9GipwS8tX
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @RyanLCollins13: Whoa😮 seems like a pretty major finding: "...variants in the MAF range of 0.0001 to 0.1 explained 0.54 and 0.51 of heri…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
🤯🤯🤯 Rare variants explain a large proportion of the missing heritability. Major findings answering one of the biggest questions in modern genetics! 🧬
RT @euanashley: New from Visscher: Recovery of trait heritability from whole genome sequence data https://t.co/iGYrdSv08l https://t.co/j0Od…
Top #tweeted story in #bioscience: Recovery of trait heritability from whole genome sequence data | bioRxiv https://t.co/ikGdHjNNSL, see more https://t.co/kME3G1o122
New from Visscher: Recovery of trait heritability from whole genome sequence data https://t.co/iGYrdSv08l https://t.co/j0OdtkKspn
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @casey6r0wn: RIP missing heritability? https://t.co/TnhH8A6KSw
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @primalpoly: tl;dr: you no longer need twin/family studies to estimate heritability of a trait. You can just do it from big samples of p…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
This could be a big step towards solving missing heritability, a major open problem in genetics. Rare SNPs in 40k WGS samples explain 100% of heritability for height, BMI. Genetic risk prediction may soon become much more accurate. https://t.co/f5M7fFx9UY
RT @RyanLCollins13: Whoa😮 seems like a pretty major finding: "...variants in the MAF range of 0.0001 to 0.1 explained 0.54 and 0.51 of heri…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @evolbrain: Holy shit - missing h2 of height is found in rare variants. This has profound consequences for the genetics of adaptation, s…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
THREAD: Considering the strong message and the novelty (very interesting work by the way) there a few questions that I’d love to know the answer to/1
RT @bendesky: This is a big deal. Rare variants account for ~50% heritability of height https://t.co/hJENAlATat
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
Preprint of our paper on trait heritability online on bioRxiv:
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
Missing heritability of complex traits and disease is accounted for by rare variants in low LD regions
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
Holy shit - missing h2 of height is found in rare variants. This has profound consequences for the genetics of adaptation, standing variation, & the limitations of PRS.
RT @bendesky: This is a big deal. Rare variants account for ~50% heritability of height https://t.co/hJENAlATat
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
Gimme a P! Gimme an E! Gimme a D! Gimme a IGREES!
RT @primalpoly: tl;dr: you no longer need twin/family studies to estimate heritability of a trait. You can just do it from big samples of p…
RT @casey6r0wn: RIP missing heritability? https://t.co/TnhH8A6KSw
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @primalpoly: tl;dr: you no longer need twin/family studies to estimate heritability of a trait. You can just do it from big samples of p…
Cumulatively variants in the MAF range of 0.0001 to 0.1 explained 0.54 (SE 0.05) and 0.51 (SE 0.11) of heritability for height and BMI... Cool!!
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
"missing" heritability is "found"!
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @MGoGuo: Wow, new work from Visscher, Yang, et al using WGS to show that for height and BMI, variants with MAF 0.0001 to 0.1 account for…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @primalpoly: tl;dr: you no longer need twin/family studies to estimate heritability of a trait. You can just do it from big samples of p…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @karls_es: Mistery solved: Most of the missing heritability for height is recovered from low frequency variants in low LD regions. https…
Something interesting here. I know @DrMJoyner will be interested or will have already read it!
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @casey6r0wn: RIP missing heritability? https://t.co/TnhH8A6KSw
RT @bendesky: This is a big deal. Rare variants account for ~50% heritability of height https://t.co/hJENAlATat
RT @biorxiv_genetic: Recovery of trait heritability from whole genome sequence data https://t.co/wxb61gjxQn #biorxiv_genetic
RT @primalpoly: tl;dr: you no longer need twin/family studies to estimate heritability of a trait. You can just do it from big samples of p…
RT @RyanLCollins13: Whoa😮 seems like a pretty major finding: "...variants in the MAF range of 0.0001 to 0.1 explained 0.54 and 0.51 of heri…
tl;dr: you no longer need twin/family studies to estimate heritability of a trait. You can just do it from big samples of people where you (1) measure the trait and (2) get their DNA (e.g. from saliva samples) and do fine-grained genotyping.
Recovery of trait heritability from whole genome sequence data [NEW RESULTS] https://t.co/6uWvlfDXqo
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
RT @xrtGenomics: Wow!! WGS finds the missing heritability; Its in rare variants with low LD. https://t.co/hvibbC91Y6
RT @biorxivpreprint: Recovery of trait heritability from whole genome sequence data https://t.co/THpYxlpWHN #bioRxiv
RT @phl43: "Cumulatively variants in the MAF range of 0.0001 to 0.1 explained 0.54 (SE 0.05) and 0.51 (SE 0.11) of heritability for height…
RT @arundurvasula: This is just to say I have found the heritability that was missing in the genome and which you were probably writing…
Wow, new work from Visscher, Yang, et al using WGS to show that for height and BMI, variants with MAF 0.0001 to 0.1 account for > 50% of heritability, thus being the long sought-after "missing" or "phantom" heritability.
Mistery solved: Most of the missing heritability for height is recovered from low frequency variants in low LD regions. https://t.co/CrVaFMGuca
RT @GWAS_lit: Recovery of trait heritability from whole genome sequence data https://t.co/8yYNUswOfp https://t.co/COieU36YXM
RT @RyanLCollins13: Whoa😮 seems like a pretty major finding: "...variants in the MAF range of 0.0001 to 0.1 explained 0.54 and 0.51 of heri…